Data DependenceWilliam Poole*President, Federal Reserve Bank of St. Louis Middle Tennessee State University Annual Economic Outlook ConferenceMurfreesboro, Tenn. Sept. 29, 2006 *I appreciate comments provided by my colleagues at the Federal Reserve Bank of St. Louis. William T. Gavin, vice president in the Research division, provided special assistance. I take full responsibility for errors. The views expressed are mine and do not necessarily reflect official positions of the Federal Reserve System.--------------------------------------------------------------------------------Data DependenceI am very pleased to participate in the Annual Outlook Conference here at Middle Tennessee State University. However, perhaps strangely, I’ll not say much about the outlook. Others are better qualified than I to discuss that subject. My topic is how the Fed adjusts policy when the economy departs from the central tendency outlook. Of course, forecasters commonly have somewhat different views but each forecaster’s central tendency, or baseline, forecast provides his or her best guess as to how the economy will evolve. However, forecasters also need to be able to say something about probabilities of other outcomes. The probability distribution of possible outcomes is substantially affected by policy responses to deviations from the baseline outlook if and when those deviations occur. And, although I say “if and when,” everyone in the forecasting business knows that our knowledge of forecast errors requires that we put much more weight on the “when” than the “if.”The views I express here are mine and do not necessarily reflect official positions of the Federal Reserve System. I thank my colleagues at the Federal Reserve Bank of St. Louis for their comments. Bill Gavin, vice president in the Research division, provided special assistance. However, I retain full responsibility for errors.Let me also note at the outset that this speech is something of a companion to another speech I gave recently, “Understanding the Fed,” which is available on the St. Louis Fed web site.(1)Some BackgroundMore than three years ago now, in June 2003, the Federal Open Market Committee (FOMC) set its federal funds rate target at a 40-year low of 1 percent completing, as it turned out, a series of reductions from a rate of 6½ percent in 2000. The policy statement accompanying the change in the policy target concluded with a concern about an “unwelcome substantial fall in inflation.” The decline in the inflation rate was only one of a string of surprises to which the FOMC reacted as it brought its target rate down. The most shocking of the surprises, of course, was the terrorist attack on the United States on Sept. 11, 2001. It would be time consuming, but not difficult, to recount this history pointing to the data releases and events that led the FOMC to reduce its target rate between early 2001 and June 2003; such an account would provide a clear illustration of what is meant by “data dependence.”The roughly two-year period after June 2003 was quite different in the sense that monetary policy does not appear to have been very data dependent. Following its meeting on Aug. 12, 2003, the FOMC issued a statement that said, among other things, that “the Committee believes that policy accommodation can be maintained for a considerable period.” The funds rate target remained at 1 percent for a full year. The era of a 1 percent target ended when the FOMC raised the target to 1¼ percent on June 30, 2004, a policy adjustment the FOMC had signaled at its previous meeting in May. By then, as the economy’s recovery continued, there was no doubt that the FOMC would have to raise its policy target by a substantial amount to support its long-term inflation objective. In each of the next 16 consecutive meetings, the FOMC voted to raise the target for the federal funds rate by 25 basis points, finally pausing at 5¼ percent in August of this year. It appeared to some that policy was on autopilot, as the FOMC raised the target by 25 basis points meeting after meeting, apparently independent of incoming information. That view, I believe, was mistaken. When the FOMC began the series of rate increases, in June 2004, the statement included this sentence: “Nonetheless, the Committee will respond to changes in economic prospects as needed to fulfill its obligation to maintain price stability.” Similar language has appeared in every statement since and the minutes of the meetings have emphasized the same point. What happened over the 18 months after June 2004 was, basically, that incoming data indicated that the economy was so close to the track expected earlier that there was no reason to depart from the “measured pace” of rate increases of 25 basis points at every meeting. My purpose today is to discuss in a systematic fashion the dependence of policy on new information. I can give you a feel, though not a formula, for why policy decisions are sometimes more data dependent than at other times. When the target rate was at 1 percent, or only modestly above, it was clear that rates had to rise, but a sufficiently large surprise would have led the FOMC to stop, slow or accelerate the increase. In the event, data surprises were minimal and the FOMC raised the target by 25 basis points 17 times in a row. Increasingly, though, as the FOMC raised the target funds rate, policymakers became more sensitive to the possibility that data surprises could alter the policy course. As it turned out, the decision to stop raising rates was determined, in my mind, less by data surprises than by the economy’s slowing more or less as had been expected many months before. The August FOMC meeting turned out to be a good time to pause to take stock of where the economy stood and the likely course of events going forward. Whether the August decision to hold the target funds rate unchanged will turn out to be a pause in the process of raising rates, a longer-lasting stop or even the peak, will depend on the economy’s evolution in coming months. The Model To operate monetary policy effectively and to understand how policy actions affect the economy, the Federal Reserve relies heavily on economic theory developed over the span of many decades. The theoretical framework is complicated in its technical form and implementation but quite straight forward in its bare-bones abstract framework. The real economy evolves along a trend that is buffeted by a variety of economic shocks. Inflation evolves along a trend that is determined by monetary policy and also buffeted by these same economic shocks. Although these shocks drive the business cycle and make the near-term uncertain, expectations about longer-term trends in both real output growth and inflation have become quite stable.Long-run output growth has almost always been fairly predictable because its trend is determined by the trends in the growth of real factors such as the labor force, the capital stock, and the level of technology in science, industry and management. These trends evolve slowly; since World War II, real growth has fluctuated around a 3½ percent average, and forecasts of future growth tend to be centered on that number or perhaps somewhat lower because labor force growth is slowing as baby boomers retire.Inflation, on the other hand, has not always been so predictable. Before 1987, there were wide swings in the inflation trend, and, unlike the case for real GDP, long-horizon forecasts of inflation were actually more uncertain than short-horizon forecasts.(2) Today, after a quarter century of effort by the Fed to actively contain inflation, inflation has also become more predictable over all horizons, and forecasts over longer horizons are now much more accurate than those over shorter horizons.(3) Evidence that long-term inflation has become more predictable is important, because it means that the Fed has found a way to anchor the inflation trend. Thus, our basic model is of an economy in which both real growth and the inflation rate are buffeted by economic shocks in the short run but then tend to return to predictable long-term trends. The fluctuations of both output and inflation around trends have moderated a great deal over the past 25 years, partly and importantly because of better monetary policy. This better policy is due to the Fed concentrating on its objective for long-run price stability through a more systematic reaction to incoming information about the economic shocks. At one time, many economists believed that there was an inherent tension between stabilizing inflation and stabilizing the real economy. Over the past 25 years, we have learned that a condition for stabilizing the real economy is stabilizing long-run inflation expectations. Thus, one of the most important things to understand about the dependence of monetary policy actions on arriving information is that the Federal Reserve has a deep commitment to achieving a long-run outcome for inflation that is in accord with its price stability objective. Put another way, short-run policy is strongly motivated by long-run considerations. Monetary PolicyA fundamental component of monetary policy is the decision about the long-run policy objective for inflation. This aspect of policy should not be data dependent. It is possible that an advance in economic knowledge will teach that we should have a different long-run inflation objective. No such advance is on the horizon, but even if it were it would not be an exception to the rule that the policy objective should be independent of incoming information about the current state of the economy. The policy objective determines the long-run inflation trend in our model and, more importantly, the nominal anchor for the economy.The reaction of policy to incoming news depends on the state of the economy relative to the trends. The private sector needs to know the Federal Reserve’s inflation objective so that it knows how to view fluctuations around the trend. Recently, several individual FOMC members have characterized the long-run inflation goal as a “comfort zone of 1-2 percent inflation” as measured by inflation in the chain price index for personal consumption expenditures. Although the FOMC itself has not adopted a formal, quantitative inflation objective, several members, including me, have said that they believe that greater clarity about the long-run objective would help both the Committee and the markets to make more informed decisions.It is much easier to agree on a long-run inflation objective than on short-run policy actions consistent with the objective. There is agreement on two conflicting principles. First, it is all too easy to overreact to short-run developments. Agreement on that principle is reflected in the FOMC’s emphasis on core inflation—inflation measures excluding volatile food and energy prices—as a guide to short-run policy. Moreover, above-trend inflation may be acceptable under some circumstances provided we are confident that past policy actions have been sufficient to slow inflation in the future. Nevertheless, there is also agreement on a second principle: It is all too easy to allow wishful thinking on inflation to delay needed tough policy decisions. The FOMC does its best to make the right choices when, as is often the case, “all too easy to overreact” collides with “all too easy to allow wishful thinking on inflation.”In one sense, long-run policy is the accumulation of individual short-run policy decisions. However, if individual decisions only reflect reactions to short-run developments in the economy, then there is no telling where long-run policy will go. The right way for the Fed to think about short-run policy decisions is that they have to be part of, or fit into, a coherent long-term plan. Market understanding of this plan is central to the determination of long-term interest rates. In general, the rate on any bond depends on expected short rates over the horizon of the bond. Thus, the ten-year Treasury bond rate depends on expectations of short-term interest rates over the ten-year horizon.Market expectations about future interest rates depend on the interaction of two interrelated sources of influence. One, obviously, concerns Federal Reserve decisions on the intended federal funds rate. Also important are expectations as to the demands for and supplies of funds in the private market. For example, with simultaneous investment and housing booms, credit demands will be high and interest rates will tend to be bid up. In pursuing its policy goals, the FOMC will be adjusting the federal funds rate as needed to keep the inflation rate low and stable. Thus, the market forms expectations about the underlying state of the economy that will bear on Fed decisions.The Federal Reserve is constantly evaluating the situation in the markets and trying to adjust the intended federal funds rate to produce a satisfactory equilibrium in the economy. When we put the Federal Reserve’s and the market’s decisions and expectations together, we have a macroeconomic equilibrium. The interaction between the Federal Reserve and the markets may be confusing at first sight and indeed was confusing to economists for generations until conceptual breakthroughs in the 1960s and 1970s clarified the issue. Market behavior depends on expectations as to what the Federal Reserve is going to do, and what the Federal Reserve is going to do depends on what the market and the economy are anticipated to do. The full rational expectations macroeconomic equilibrium occurs when the market behaves as the Federal Reserve expects and the Federal Reserve behaves as the market expects. In both cases we assume that the expectations are fully rational, by which we mean that the expectations are fully informed on the basis of all available information. The abstraction of a full rational expectations macroeconomic equilibrium provides a powerful starting point for analysis of a data dependent policy.Can the Market Predict Data Dependence? The “Taylor rule” is a stylized view of the Fed’s reaction to incoming information. In 1993, Stanford economist John Taylor proposed a simple formula relating the federal funds rate to: 1) a long-run inflation target, and 2) short-run deviations of inflation from that target and short-run deviations of real GDP from a measure of “potential real GDP.”(4) Taylor suggested that his simple relationship characterized in broad outline the actual behavior of the federal funds rate in the early years of the Greenspan FOMC. The essence of this relationship is that, in the long-run, the FOMC seeks to keep the federal funds rate roughly consistent with a level that is believed to produce a target level of inflation. Taylor assumed a target rate of inflation of 2 percent per year measured by the total Consumer Price Index (CPI). In the short run, the relationship implies that the FOMC adjusts the target federal funds rate up as either the observed inflation rate exceeds its target or real GDP exceeds potential real GDP. Conversely, under the Taylor rule, the FOMC reduces the target federal funds rate when inflation falls below its target and/or real GDP falls short of potential real GDP. The Taylor rule reflects the primacy of a long-run inflation objective while incorporating short-run stabilization efforts. The rule provides a formula for computing a baseline, or reference, interest rate that is consistent with policy achieving the Fed’s objectives for both output stabilization and price stability. I discussed the Taylor Rule in some detail in “Understanding the Fed” and refer you to that speech if you want to dig into the subject more deeply. Now I’ll turn to some comments on future Fed policy, but I want to remind you that I am speaking for myself—other FOMC participants may have different views about how future policy adjustments will depend on arriving information. All economic indicators may have implications for the evolution of the real economy and inflation. I emphasize “may” because we have to filter out as best we can possible data errors and inconsistencies across various indicators. Before I discuss future Fed policy in any detail, I begin with a warning. New information drives both market adjustments and policy changes but new information is inherently unpredictable. To gain a sense of the impact of new information on interest rates, I’ve analyzed data from the Eurodollar futures market and discussed the results in some detail in “Understanding the Fed.” The bottom line of that analysis is that forecasts embedded in the Eurodollar futures market explain 42 percent of the variance of fluctuations in the actual Eurodollar yield three months ahead. Thus, unpredictable events even over a three-month horizon are responsible for 58 percent of the variance of the Eurodollar yield. Over a six-month horizon, unpredictable events are responsible for more than 70 percent of the variance. Thus, I can discuss various scenarios but have no way of knowing which scenario will come to pass. Let’s start with the outlook for the rest of 2006. Forecasts by FOMC members and transmitted to Congress in July were 3¼ to 3½ percent growth for real GDP and an increase for the core PCE chain price index of 2¼ to 2½ percent. As for 2007, the central tendency of the FOMC members’ GDP forecasts is 3 to 3½ percent. This growth outlook should be consistent with keeping the economy close to full employment, based on the CBO forecast of potential GDP growth of 3.24 percent in 2007. As for inflation, the central tendency forecast of FOMC participants for 2007 is 2 to 2¼ percent. Thus, inflation is expected to recede only very slowly from its current level. There are two cases in which the economic news will pretty clearly predict a change in the Fed’s policy stance. If incoming economic indicators show that both output and inflation are rising above these forecasts, then in the absence of any other information we can expect that the FOMC will increase its target fed funds rate. On the other hand, if both output and inflation come in weaker than expected, we are unlikely to see further increases in the federal funds target; indeed, if economic weakness is pervasive enough the FOMC will at some point reduce the target funds rate.The most interesting—not to mention controversial and difficult—cases are those in which the outlook for inflation and output move in opposite directions. In such cases, the FOMC has to call on all its experience and judgment to reach a decision. It is very difficult for me to be precise about the judgments I am likely to reach based on incoming information because a host of considerations, some of which I cannot foresee, may enter the calculus. But I’ll make a stab at how things could play out to illustrate my thought process. A critically important consideration in my mind concerns the inflation process and the importance of the Fed’s commitment to low and stable inflation. It is my conviction that temporizing on actions to control inflation is an invitation to trouble. Accepting higher inflation, or even a continuation of the current rate of inflation, in an effort to sustain current employment levels will only lead to more grief later. Once inflation and inflation expectations rise, the economy will become less stable and reducing inflation from an elevated rate will be more costly than taking the medicine now. Having said that, if inflation pressures are easing, even if only gradually, and there is a genuine prospect that inflation will return to the comfort zone, then I see no reason to accelerate the decline in inflation by maintaining a restrictive policy in the face of declining employment. Policy needs to be as disciplined as necessary to get the job done, but not more so.The long-run inflation goal and the attitude I’ve expressed about what risks to take suggest that I will have a bias in the way I interpret incoming information. If data on the real economy come in weaker than expected—if it appears that the economy is falling below the baseline forecast path—then my bias will be in the direction of wanting to be sure that the data paint a consistent picture before I’ll advocate a policy easing. But if the picture is consistent, and inflation risk is receding, then I’ll not hesitate to advocate policy easing. What I hope the FOMC can accomplish is to retain full market confidence that the long-run rate of inflation will remain in the comfort zone. I hope that forecasters assign very low probability to inflation outcomes over the medium term of three to five years outside the comfort zone no matter what the incoming data look like. Although I am talking about inflation over a horizon well beyond the usual forecast horizon of one to two years, the long-run inflation outlook has a direct bearing on the forecast. The long bond rate today depends critically on expected inflation over the maturity of the bond. Thus, rates that enter importantly into any economic forecast, such as mortgage and corporate bond rates, depend on the long-run inflation outlook. This outlook has been quite stable in recent years, and that fact is evidence of a major monetary policy success. With long-run inflation contained, the FOMC has flexibility to respond, vigorously if necessary, to economic weakness should it arise. The FOMC brought the target federal funds rate down aggressively in 2001 in response to incoming information. Aggressive easing kept the recession mild. If the economy comes in below the baseline forecast in coming quarters, the FOMC will have room to act as aggressively as required. I have no idea what scale of easing might be appropriate, for that will depend on the nature of the incoming information. Still, I believe forecasters should assign a relatively low probability to deep recession precisely because of the FOMC’s demonstrated willingness to act aggressively as necessary.I’ve given you my take on what data dependence means and the attitudes that underlie my likely responses. I’ve also emphasized that an efficient rational expectations equilibrium requires that the market behave as the policymakers expect and policymakers behave as the market expects. The market’s evaluation of the prospects for policy is revealed in the futures markets for federal funds and Eurodollar deposits. Current futures prices predict that the fed funds target is expected to begin moving down. Because these market quotes change day by day in response to new information, I do not want to attempt to be particularly precise as to the timing—anything I write as I draft these remarks may be out of date by the time I deliver them or within a few weeks, anyway. What I can safely note is that the market’s expectation of future policy easing has been taking hold gradually since late June, say, in response to data on the real economy suggesting that real growth is slowing and inflation data suggesting that the worst may be over on that front.Although expectations about future policy actions are revealed transparently in the futures market for short-term interest rates, I want to underscore my earlier point about the limited accuracy of those forecasts. Some of the forecast misses have been pretty dramatic. For example, in December 2000 the futures market forecasts were for a decline in the Eurodollar yield of 35 basis points over the following three months and a total of 67 basis points over the 6-month period. Instead, the FOMC acted aggressively to lower the funds rate target starting in January and continuing through May 2001 by a total of 250 basis points. The FOMC acted aggressively as incoming information pointed to growing weakness in economic activity. Both the FOMC and the markets were surprised by incoming information indicating that the economy was weakening quickly and significantly.Although I cannot predict unpredictable new information, I’ve tried to provide a sense of how I might respond to new information as it arrives. I note, however, that it is rare that a single data report is decisive. The economic outlook is determined by numerous pieces of information. Important data such as the inflation and the employment reports are cross checked against other information. The FOMC is aware of possibility of data revisions and short-run anomalies. Sometimes data ought to be discounted because of anomalous behavior. An example was the increase in tobacco prices in late 1998. Tobacco prices had a transitory impact on measured inflation, both total and core indexes, during December 1998 and January 1999, but produced no lasting effect on trend inflation. Similarly, information about real activity sometimes arrives that indicates transitory shocks to aggregate output and employment. An example of such a transitory shock is the strike against General Motors in June and July 1998. Similarly, the September 2005 employment report reflected the impact of Hurricane Katrina, which was expected to be, and turned out to be, temporary from a national perspective. Transitory and anomalous shocks to the data are ordinarily rather easy to identify. Both Fed and market economists develop estimates of these aberrations in the data shortly after they occur. The principle of looking through aberrations is easy to state but probably impossible to formalize with any precision. We know these shocks when we see them, but could never construct a completely comprehensive list of such shocks ex ante.Policymakers piece together a picture of the economy from a variety of data, including anecdotal observations. When the various observations fit together to provide a coherent picture, the Fed can adjust the intended rate with some confidence. The market generally understands this process, as it draws similar conclusions from the same data.So, given policy objectives, and given a view about how policy decisions affect the economy, the central bank can in principle specify a policy rule, or response function, that guides policy adjustments in response to incoming information. To achieve a good result, the general public and market participants need to understand the objectives and the response function so that the private economy can determine its activities with full knowledge of how the central bank will act. Of course, uncertainty is an inherent characteristic of the economic world. What should be predictable are the central bank’s responses to the never ending sequence of surprises that characterize the economic environment. Market commentary often indicates frustration that the FOMC does not lay out a clearer path for policy, arguing that the FOMC is unpredictable. That view, I believe, is off base. Typically the FOMC cannot be predictable with regard to the path of the target fed funds rate because new information driving policy adjustments is not predictable. All of us would like to be able to predict the future. We in the Fed do the best we can, but the markets should not complain that the FOMC lacks clairvoyance! What the FOMC strives to do is to respond systematically to the new information. There is considerable evidence that the market does successfully predict FOMC responses to the available information at the time of regularly scheduled meetings.(5) Concluding CommentTo say that policy is data dependent means that policy changes will depend on the incoming news about the state of the economy, both real growth and inflation. That the policy setting is data dependent is a good sign. It means that policy is in a range than can be considered neutral—that is, thought to be consistent with the Fed’s longer-run policy objectives. It is important to remember that the long-run inflation objective should not be data dependent. If the objective is well understood, people will know whether the current inflation rate is above or below the desired trend. They will know how to interpret incoming information to gauge what it means for the policy stance. I believe that is just about exactly where we are today.I’ve been looking forward to your questions, and now is the time. References1. “Understanding the Fed,” Dyer County Chamber of Commerce Annual Membership Luncheon, Dyersburg, Tenn., Aug. 31, 2006 2. See Stephen K. McNees, “How Accurate Are Macroeconomic Forecasts?” Federal Reserve Bank of Boston, New England Economic Review, July/August 1988, pp. 15-36.3. See evidence on forecast errors cumulated over 3-, 12-, and 24-month intervals from 1997 through 2006 in William T. Gavin and Kevin L. Kliesen, "Forecasting Inflation and Output: Comparing Data-Rich Models with Simple Rules," Federal Reserve Bank of St. Louis Working Paper 2006-054A, September 2006..4. John B. Taylor, “Discretion versus Policy Rules in Practice,” Carnegie-Rochester Conference Series on Public Policy, 39, December 1993, pp.195-214. Taylor compared the values of his formula against the observed history of the funds rate from 1987 through 1992.5. See for example: William Poole, How Predictable is Fed Policy?, October 4, 2005,
[관련키워드]
[뉴스핌 베스트 기사]
사진
위고비에 도전한 새 비만약 '에페' 가격은?
[서울=뉴스핌] 김신영 기자 = 한미약품의 국산 비만 신약 '에페'가 위고비와 마운자로가 86%를 장악한 국내 비만치료제 시장에 뛰어든다. 후발주자인 만큼 자체 생산을 통한 가격 경쟁력과 국내 환자 임상 데이터, 기존 병·의원 영업망을 앞세워 선발 제품 중심의 처방 시장을 파고든다는 전략이다.
관건은 가격 이외의 경쟁력을 실제 처방 전환으로 연결할 수 있느냐다. 위고비와 마운자로는 글로벌 시장에서 이미 높은 인지도와 장기간의 처방 경험을 쌓은 데다 대표 임상에서 높은 체중 감량 효과를 제시했다. 에페가 연매출 1000억원 목표를 달성하려면 가격에 민감한 신규 수요를 확보하는 동시에 기존 GLP-1 치료제 사용자의 선택까지 끌어와야 한다.
17일 제약·바이오업계에 따르면 한미약품은 오는 10월 식품의약품안전처 품목허가를 목표로 에페(성분명 에페글레나타이드) 출시를 준비하고 있다. 허가 이후 연내 출시가 목표다.
한미약품 본사 전경 [사진=한미약품]
◆ 가격 경쟁력 갖췄지만…출시 이후 기존 제품 인하 변수
에페는 한미약품이 자체 개발한 주 1회 투여 글루카곤 유사 펩타이드(GLP-1) 계열 비만치료제다. 약물이 체내에서 오래 작용하도록 한 한미약품의 지속형 플랫폼 기술 '랩스커버리'가 적용됐다.
에페가 진입할 시장은 이미 선발주자 중심으로 2강 구도가 형성돼 있다. 의약품 시장조사기관 아이큐비아에 따르면 국내 비만치료제 시장은 2024년 2426억원에서 지난해 8195억원으로 1년 만에 3배 이상 확대됐다. 이 중 위고비와 마운자로 판매액은 각각 4833억원, 2209억원으로 두 제품이 전체 시장의 약 86%를 차지했다.
후발주자인 에페가 내세운 무기는 가격이다. 한미약품은 최종 공급가를 공개하지 않았지만 업계와 증권가에서는 4주 투약 기준 10만원대 가격이 거론된다. 현재 위고비의 시작용량인 0.25㎎의 4주분 공급가는 21만6000원, 마운자로의 시작용량인 2.5㎎은 27만8000원 수준이다.
한미약품이 가격 경쟁력을 확보할 수 있는 배경에는 자체 생산체제가 있다. 회사는 경기도 평택 바이오플랜트에서 에페를 직접 생산한다. 외부 생산 의존도를 낮춰 공급 안정성을 높이는 동시에 가격을 낮추겠다는 구상이다.
하지만 가격만으로 선발주자의 벽을 넘을 수 있을지는 미지수다. 국내에서 가장 먼저 출시된 비만치료제인 위고비는 마운자로의 국내 출시를 앞둔 지난해 용량별 차등가격제를 도입하면서 시작용량 공급가를 기존 37만2000원에서 21만6000원으로 약 42% 낮췄다. 경쟁 제품 등장에 맞춰 선발주자가 가격을 조정한 전례가 있는 만큼 에페 출시 이후 추가 가격 경쟁이 벌어질 가능성도 제기된다.
비만치료제의 핵심 경쟁력은 체중 감량 효과다. 한미약품이 공개한 에페 임상 3상 40주차 중간 결과에서 평균 체중 감소율은 9.75%였다. 체중이 5% 이상 감소한 환자는 79.42%, 10% 이상은 49.46%, 15% 이상은 19.86%였다.
선발 제품들은 글로벌 임상에서 더 높은 체중 감소율을 제시했다. 위고비는 비만 또는 과체중 성인 1961명을 대상으로 한 STEP 1 임상에서 68주 투여 후 평균 체중이 14.9% 감소했다. 체중이 5% 이상 줄어든 환자는 86.4%, 10% 이상은 69.1%, 15% 이상은 50.5%였다.
마운자로는 비만 또는 과체중 성인 2539명을 대상으로 한 'SURMOUNT-1' 임상에서 72주 후 평균 체중 감소율이 5mg 투여군 15.0%, 10mg 19.5%, 15mg 20.9%로 나타났다. 15mg 투여군에서는 70.6%가 체중을 15% 이상 줄였고, 56.7%는 20% 이상 감량했다.
다만 에페와 위고비, 마운자로의 임상은 투약 기간과 대상 환자, 용량과 시험 설계 등이 달라 체중 감소율을 단순 비교해 우열을 판단하기에 한계가 있다. 현재 공개된 에페의 임상 수치는 40주차 3상 중간 결과다.
한미약품 비만 신약 '에페' 로고 [사진=한미약품]
◆ 국내 환자 448명 임상으로 차별화, 브랜드·시장 경험은 숙제
이에 한미약품이 강조하는 에페의 차별점은 국내 환자를 대상으로 직접 확보한 임상 데이터다. 에페 임상 3상은 국내 성인 비만 환자 448명을 대상으로 실시했다. 위고비 역시 한국인을 포함한 아시아 환자 대상 임상을 진행했지만 에페는 3상 전체를 국내 비만 환자로 구성했다.
한미약품은 국내 환자로 구성된 임상을 통해 한국 진료현장에서 참고할 수 있는 데이터를 확보했다는 점을 차별화 요소로 내세운다. 다만 국내 환자 대상 임상이라는 사실 자체가 기존 치료제보다 높은 효능이나 안전성을 의미하는 것은 아니다.
임상에서 체질량지수(BMI) 30㎏/㎡ 미만 여성 환자의 평균 체중은 12.20% 감소했다. 한미약품은 이를 토대로 고도비만 환자뿐 아니라, 비만도가 낮거나 장기적인 체중 관리가 필요한 환자까지 처방 수요를 넓힐 수 있을 것으로 보고 있다.
한미약품은 에페가 GLP-1 비만치료제의 대표적인 부작용인 구역과 구토 등 위장관계 이상반응이 기존 제품 대비 낮다는 점도 내세우고 있다. 구역과 구토는 비만치료제의 투약을 중단하게 하는 요인으로 거론된다.
그러나 브랜드 인지도와 시장 경험에 있어서는 선발주자의 우위가 뚜렷하다. 위고비와 마운자로는 각각 노보 노디스크와 일라이 릴리라는 글로벌 대형 제약사의 제품으로, 해외에서 이미 대규모 판매와 처방 경험을 축적했다. 환자들의 실제 사용 경험과 장기 데이터가 쌓였다는 점도 후발주자인 에페가 단기간에 따라잡기 어려운 부분이다.
반면 한미약품은 국내 병·의원을 대상으로 구축한 영업망과 자체 생산능력을 갖추고 있다. 기존 영업망을 치료제 처방으로 연결할 수 있느냐가 후발주자의 한계를 극복할 변수가 될 것이라는 평가가 나온다.
한미약품은 에페를 연 매출 1000억원 이상 품목으로 육성한다는 목표를 세웠다. 목표 달성을 위해서는 가격 경쟁력 등 회사가 내세운 강점을 처방 확대로 연결할 수 있어야 한다.
한 업계 관계자는 "에페는 가격과 국내 환자 대상 임상 데이터에서 차별화 요소가 있지만 위고비와 마운자로는 높은 인지도와 처방 경험을 확보한 제품"이라며 "후발주자인 만큼 실제 진료 현장에서 의사와 환자의 선택을 얼마나 바꿀 수 있느냐가 시장 안착의 관건"이라고 봤다.
sykim@newspim.com
2026-09-17 15:33
사진
李, 일정 최소화 '18일 회견' 준비 몰두
[서울=뉴스핌] 김미경 기자 = 이재명 대통령이 18일 기자회견을 하루 앞둔 17일 공식 일정을 최소화하고 회견 준비에 몰두했다.
이 대통령은 지난 14일부터 3일간 중앙아시아 5개국 정상과 연쇄 회담을 하고 1차 한-중앙아시아 정상회의를 주재하며 외교 일정으로 숨가쁘게 지냈다.
이 대통령이 기자회견 일정을 18일로 정한 것도 외교 일정을 모두 마무리하고 하루 정도 준비하는 시간이 필요하다는 판단을 한 것으로 보인다.
이 대통령은 이날 통상 목요일에 열던 수석보좌관회의도 없이 파티 비롤 국제에너지기구(IEA) 사무총장을 접견하는 일정만 소화한다.
이재명 대통령이 취임 1주녁 기자회견에서 주택공급을 위해 재건축·재개발도 속도를 내야한다고 말했다. [사진=청와대]
◆청와대 "국민이 궁금한 국정 현안, 진솔하게 소통할 것"
이 대통령은 비롤 사무총장 접견 외 나머지 시간은 회견 준비에 쓸 것으로 예상된다. 이 대통령은 참모들에게서 분야별 핵심 쟁점과 추진 방향을 보고받고 예상 질문을 추려 답변을 거듭 다듬는 것으로 알려졌다.
회견은 18일 오전 10시 청와대 영빈관에서 열린다. 모두발언과 질의응답, 마무리 발언을 합쳐 90분가량 진행한다는 계획이다. 기자회견에는 내·외신 기자 150여 명이 참석한다.
질의응답은 정치·외교와 정책·경제 두 분야로 나눠 주제 제한 없이 진행하고 실시간 국민 댓글도 소개한다.
청와대는 회견 제목을 수식어 없이 '이재명 대통령 기자회견'으로 정했다. 회견장 배경막에는 '국민의 뜻, 국민의 삶, 더 살피겠습니다'라는 문구를 건다.
성기홍 청와대 홍보소통수석은 지난 15일 브리핑에서 "대통령의 확고한 개혁 의지와 민생 최우선 국정 기조, 더 단단한 국민 통합의 메시지를 전하는 자리가 될 것"이라고 했다. 이어 "국민이 궁금해하고 듣고 싶어 하는 국정 현안을 진솔하고 충실하게 소통하려 한다"고 설명했다.
[서울=뉴스핌] 이건주 기자 = 8일 오전 서울 중구 하나은행 딜링룸에서 이재명 대통령 취임 1주년 기자회견 '대체불가 대한민국'이 생중계되고 있다. 2026.06.08 kunjoo@newspim.com
◆연임·공소취소·파병 정치 현안에 부동산·증시 민생 현안 산적
회견의 관심은 산적한 현안에 이 대통령이 과연 명확한 입장을 밝힐 것인지다.
특히 공소 취소와 연임 헌법 개정(개헌) 논란은 피할 수 없는 질문이다. 집권 여당인 더불어민주당은 '조작기소 특검법안'을 9월 중 처리하겠다고 예고했다.
특검에 공소취소 권한을 줄지가 핵심 쟁점이다. 이 대통령 사건 공소 취소를 앞장서 주장했던 김승원 의원이 법무부 장관 후보자로 지명됐고 민주당 주도로 국회 인사청문 경과보고서가 채택됨에 따라 야권의 공세는 더 거세졌다.
인사 검증 문제에 대한 언론의 질의도 예상된다. 용혜인 전 성평등가족부 장관 후보자는 자진사퇴했고 김승원 후보자는 '식약처 청탁 의혹'에 휩싸였다.
미국 요청에 따른 호르무즈 해협 파병 검토와 대미 투자 협상 관련 질문도 이 대통령에게는 고난도 문제다.
민생 현안으로는 부동산이 첫손에 꼽힌다. 정부는 취임 후 8·13 대책을 포함해 6차례 부동산 대책을 내놨다.
하지만 한국부동산원 집계에 따르면 서울 아파트 주간 매매 가격이 지난해 2월 첫째 주부터 83주 연속 올랐다.
문재인 정부 시절 세운 최장 기록(85주)에 바짝 다가섰다. 강남 3구 집값은 약세로 돌아섰지만 수도권 중저가 아파트값이 오르고 전세 매물 품귀와 월세 상승이 이어지고 있다. 부동산 정책 효과에 대한 논란이 적지 않다.
이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대]
◆이 대통령 "임기는 헌법상 명확하게 제한"…이번엔 어떤 답 낼까
이 대통령이 앞서 일부 현안에 짧게 입장을 밝히기는 했지만 대체로 원론적 언급에 그친 경우가 많았다.
연임 개헌 논란을 두고는 프랑스 국빈방문 중이던 지난 9일(현지시간) 파리 동포 오찬간담회에서 "(대통령) 임기는 헌법상 명확하게 제한돼 있다"고 했다.
취임 초 해외 순방을 자주 다니는 이유를 설명하는 차원의 언급이었지만 연임 논란을 의식한 우회적 입장 표명이라는 해석이다.
공소 취소와 관련해서는 지난 6월 8일 진행한 취임 1주년 회견에서 "(조작기소 여부의) 진상 규명은 해야 한다"는 원론적 답변을 내놨다.
이 대통령은 당시 공소 취소 특검에 대한 질문을 받고 "결론적으로 법과 상식대로 하면 된다"며 "최소한의 진상규명을 해야 한다"고 했다.
이 대통령은 "뭔가 문제는 있어 보인다. 주관적 판단은 있지만 객관적으로도 문제가 있어 보이는 것이 꽤 많다"며 "잘못된 게 있으면 바로 잡고 없으면 그냥 놔두면 된다. 잘못됐으면 취소하고 잘못된 게 아니면 놔두는 것"이라고 했다.
사실상 공소가 잘못됐으면 바로 잡아야 한다는 취지의 설명이었다.
◆여권에서도 "공소취소·연임 명확한 입장 내야" 목소리 강해
야권뿐 아니라 여권에서도 이 대통령이 민감한 현안에 대해 명확한 입장 표명을 해야 한다는 목소리가 강하다.
장동혁 국민의힘 대표는 이날 최고위원회의에서 "기자회견이 의미가 있으려면 그동안의 오만과 무능부터 국민에게 사과해야 한다"며 "부동산과 이란 파병 문제 등 모든 정책에서 국정 기조 대전환을 선언하고 국민이 납득할 분명한 답을 내놓길 바란다"고 요구했다.
한병도 민주당 원내대표는 정책조정회의에서 "기자회견은 국민 목소리를 경청하고 국정 현안을 두고 진솔한 대화를 나누는 소통의 장이 될 것"이라고 강조했다.
이광재 민주당 의원은 "공소 취소는 정무적이고 정치적인 문제이니 대통령이 언급할 것으로 본다"고 했다.
여권의 한 중진 의원은 "대통령이 연임 개헌이나 공소 취소와 관련해 명확한 입장을 내놓지 않는다면 향후 국정 운영이 쉽지 않을 것"이라고 우려했다.
이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대]
◆9주 연속 지지율 하락…추석 전 기자회견, 반등 할까
이번 기자회견은 추석 연휴를 앞두고 열리는 만큼 지지율 반등의 분수령으로 꼽힌다.
여론조사 전문기관 리얼미터가 14일 공개한 9월 2주차 주간동향(에너지경제신문 의뢰, 7~11일, 무선 자동응답 방식 조사, 표본오차는 95% 신뢰수준에 ±2.0%포인트, 중앙선거여론조사심의위원회 홈페이지 참조)을 살펴보면 이 대통령의 국정수행 긍정평가는 9주 연속 하락해 취임 후 최저치인 33.8%였다. 부정평가는 63.3%로 처음 60%대에 올라섰다.
리얼미터는 외교 행보에도 개각 인선 논란과 호르무즈 파병 검토, 부동산 정책 불확실성이 겹친 데다 진보층과 20대 이탈이 더해진 것을 하락 주요 원인으로 분석했다.
한국갤럽이 17일 발표한 '2026 대한민국 신뢰도 조사'(시사IN 의뢰, 6~8일, 유선전화와 휴대전화 무작위 전화걸기 전화면접조사)에서는 이 대통령이 정치인 중 2위로 내려앉았다. 이 대통령은 2021년 이후 해당 조사에서 줄곧 가장 신뢰하는 정치인 1위였다. 올해 조사에서는 한동훈 무소속 의원에게 1위를 내줬다.
이 대통령에 대한 신뢰도 조사에서는 '신뢰한다' 35.9%, '불신한다' 50.4%였다. 지난해 조사에서는 이 대통령을 신뢰한다는 응답이 51.2%, 불신한다는 응답이 34.1%였다. 신뢰와 불신의 국민 평가가 1년 만에 뒤집어졌다.
the13ook@newspim.com
2026-09-17 14:37












