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President's Speech

Speech to the First Annual Conference of the Risk Management Institute
Singapore via video-conference


The U.S. Economy and Monetary Policy

Good afternoon, everyone. It's a pleasure to have the opportunity to speak to the inaugural research conference of the Risk Management Institute, a joint effort of U.C. Berkeley and the National University of Singapore. I'm especially gratified that the San Francisco Fed is cosponsoring this event with the Monetary Authority of Singapore. My invitation to speak to you today was tendered by Andy Rose, who was my colleague and coauthor when I was at U.C. Berkeley, so, naturally, I was delighted to accept. I last was in Singapore in 1995, to attend the Monetary Authority's 25th birthday celebration. My memories of that trip and of the interesting and gracious people I met remain vivid. At that time, I visited as a member of the Federal Reserve Board of Governors. Today, as the President of the San Francisco Fed, I have an even keener interest in economic issues in Asia, because they are a special focus of research at the Bank's Center for Pacific Basin Studies. Though I cannot be with you, I'm glad that Reuven Glick, our Group Vice President of International Research, is representing the Bank and presenting his work.

This afternoon I plan to talk about the outlook for the U.S. economy and the prospects for monetary policy. I will concentrate on several important factors shaping that outlook, including the pricing of risk in international financial markets, which is the focus of this conference. Before I begin my formal remarks, I would like to note that my comments represent my own views and not necessarily those of my colleagues in the Federal Reserve System.

As many of you probably know, the Federal Open Market Committee last met on June 27 and 28 and voted to hold the federal funds rate, our main policy tool, unchanged at 5¼ percent. To most observers of the Fed, the decision probably had a familiar ring to it, because the funds rate has been kept at that level for the last twelve months. Indeed, my views concerning the logic of this decision will also have a familiar ring to anyone who has heard me discuss monetary policy during the past year. To my mind, the reason for adopting and maintaining the current stance of policy is that it promises to keep the overall economy on an adjustment path where growth is moderate and sustainable. The virtues of this path are that it avoids exposing the economy to unnecessary risk of a downturn, while, at the same time, it is likely to produce enough slack in goods and labor markets to relieve inflationary pressures. I believed a year ago, and still believe now, that such a path is likely and will enable us to achieve our dual mandate—low and stable inflation and maximum sustainable employment.

Although the federal funds rate has remained unchanged for the past year, a number of developments over that time in both the U.S. and world economies have warranted our close attention as well as our deliberate consideration about the appropriate policy response. I plan to focus on several of these developments today, and, in particular, the risks they may still pose in diverting us from the desired path.

One issue concerns the possibility and potential consequences of a shift in risk perceptions in international financial markets. There are now numerous indications that risk premiums are notably low—in the U.S. and also globally. One indication is the low level of long-term bond rates compared with expected future rates on short-term debt—in other words, an unusually low term premium.1 Other indications can be found in the very low options-based implied volatilities on most types of financial instruments, including equities, debt, and exchange rates, in the narrow interest rate spreads between foreign securities and LIBOR, and in narrow spreads for credit risk on a wide array of assets including, with some notable exceptions, corporate debt, commercial real estate, and residential mortgages.

One reason that risk premiums may be low is precisely because the environment is less risky: the volatility of output and inflation has declined substantially in most industrial countries since the mid-1980s, and a number of financial developments associated with technological change and deregulation have reduced transactions costs, diversified and expanded the variety of credit providers, and fostered the creation of new instruments for efficiently allocating and pricing risk. In addition, the health of corporate balance sheets has improved dramatically, and household delinquency rates, including those on residential mortgages, have generally been quite modest.

At the same time, however, the concern has been expressed that some investors may be underestimating risks in both domestic and foreign markets.2 For example, in foreign markets, low borrowing costs have attracted money into such investment strategies as "carry trades," where investors borrow at lower rates in one currency and invest, unhedged, in higher-yielding bonds in another currency. This strategy obviously exposes investors to substantial exchange rate risk, which they may be underestimating. In the U.S., the rapid rise of lending at variable rates in the subprime mortgage market may have reflected an unduly sanguine view of the underlying risks; as we have seen, some households, large mortgage lenders, and hedge funds have felt the pinch of the problems in this market.

The low long-term rates and low risk premiums that have prevailed in financial markets over the last several years mean that overall financial conditions have been notably more accommodative than suggested by the current level of the real federal funds rate. Given that, a shift in risk perceptions would tend to push longer-term rates and credit spreads up, restraining demand worldwide.3

In fact, in U.S. financial markets, we have seen developments that might suggest to some that such a change may be starting. For example, in response to the problems in the subprime variable rate mortgage market, spreads on certain debt and credit default swaps linked to those instruments have recently moved up substantially. In addition, there has recently been some tightening of lending standards and higher pricing of debt being issued in connection with private-equity financed leveraged buyouts. These recent reassessments of risk premiums suggest to me that they are focused on certain targeted instruments and therefore essentially represent the market's appropriate response to the discovery of a higher probability of specific adverse events. Nonetheless, I also believe such developments are worth watching with some care, since there is always the possibility that they do presage a more general and pronounced shift in risk perceptions.

A recent noteworthy development is the recent jump in intermediate and long-term interest rates. By mid-June, the nominal yields on five- and ten-year Treasuries had shot up by nearly 50 basis points above their May averages, and the conventional mortgage rate rose by nearly 35 basis points. Based on evidence from Treasury Inflation Protected Securities, the bulk of these increases was accounted for by real yields, while a smaller share was due to compensation for inflation.

But I would not say that these increases in long-term rates necessarily reflect a significant shift in risk perception. Rather, I would point to the fact that they coincided with a sharp upward shift in the expected funds rate path, as suggested by the futures market. This upward shift followed many months during which markets anticipated that the economy would weaken and that the Fed would respond by cutting interest rates fairly substantially. This view prevailed for some time, even though the FOMC's policy statements have continually emphasized that its predominant concern was the possibility that inflation would not moderate as expected. So I suspect that the markets and the Committee have become more closely aligned, sharing the view that growth in the U.S. is, and is likely to remain, healthy. In further support of this view, stock market values have risen and implied volatilities have been flat or trended down, as we continue to get stronger news on overall economic growth. Moreover, these developments—robust economic data, rising long-term rates, higher expected policy paths and climbing stock market indexes—are global phenomena, occurring in many industrialized countries.

Insofar as the rise in longer-term rates seems to be a response to favorable economic conditions—developments that have been part of my own forecast for some time—it has not had a big effect on my overall assessment of the economic outlook. For the very same reason, this rise in longer-term rates does not quell my concerns about a reversal in risk perceptions, a possibility which itself could pose a downside threat to the global economy.

With that perspective on recent financial developments in mind, let me now turn to an explicit discussion of the U.S. economy and the outlook for growth and inflation. Beginning in the second quarter of 2006, real GDP growth moderated noticeably, registering 2 to 2½ percent rates in the final three quarters of 2006, somewhat below most estimates of the economy's potential growth rate. Growth in the first quarter of 2007 was notably weaker, but a good part of that was due to the temporary effects of business inventories and net exports. Based on partial monthly data, it seems likely that there was a bounce-back in the second quarter, with growth averaging a modest rate for the first half of the year as a whole. My expectation is for moderate growth during the remainder of this year and in 2008.

I'd like to highlight developments in three sectors that will have an important influence on whether this forecast proves accurate. Two of them—personal consumption expenditures and exports—have been quite robust but are expected to slow moderately. The third is residential investment, which has been quite weak, but it is expected to have a much less negative impact on overall activity going forward. Thus, overall real GDP in the coming period will depend importantly on how the cross-currents among these three sectors play out.

Personal consumption expenditures have been the main engine of growth in recent years; indeed, with employment growth strong and equity and housing wealth rising, American consumers outspent their earnings, and that resulted in a personal saving rate that has been in negative territory since early 2005. Going forward, at least some of the growth in consumption can be expected to diminish, as increases in housing wealth have slowed dramatically and energy prices have moved back up this year.

Another source of strength in recent years has been the very strong world economy. Foreign real GDP—weighted by U.S. export shares—advanced at robust rates of 3¾ to 4 percent in 2004 through 2006, and this growth has been widespread, affecting nearly every continent. With the trade-weighted dollar falling over this same period, U.S. exports have been strong—real exports increased by an average of nearly 8 percent during those three years. Partly for this reason, U.S. net exports, which consistently weighed growth down from 2000 to 2005, actually gave it a lift during 2006. Assuming a modest deceleration in world economic activity, net exports seem likely to "turn neutral"—neither retarding nor stimulating growth in the year or so ahead.

Of course, a big drag on growth over the past year has come from residential construction. Housing is likely to remain an important source of weakness, so let me take a few moments to discuss it in detail. The cooling in the housing sector has, of course, been in part a response to a rise in financing costs. Interest rates on variable-rate mortgages have risen in recent years along with other short-term rates. However, until a few weeks ago, traditional fixed mortgage rates were actually down somewhat from their level at the beginning of the Fed rate tightening in mid-2004. With the recent increases, these rates now also are up. I should note that higher borrowing costs are not the only explanation for the recent cooling; it's likely that it also is a drop in demand that will be reflected in a necessary correction in house prices after years of phenomenal run-ups that ultimately proved to be unsustainable.

Since the end of 2005, activity in this sector has contracted substantially. Indeed, over the past four quarters, the level of residential investment spending declined more than 16 percent in real terms. And during that period, this sector—which represents only a little more than 5 percent of U.S. GDP—has taken a large toll on overall activity, subtracting a full percentage point from real GDP growth.

The more forward-looking indicators of conditions in housing markets have been mixed recently. Housing permits and sales have been weak. House prices at the national level either have continued to appreciate, though at a much more moderate rate than before, or have fallen moderately, depending on the price index one considers. Looking ahead, futures markets are expecting small price declines in a number of metropolitan areas this year. Finally, and importantly, inventories of unsold new homes remain at very high levels, and these most likely will need to be worked off before we see a rebound in housing construction.

The prospects for the housing market may also be affected by developments in the subprime mortgage market. I should note that the Fed pays close attention to these developments, not only because of their potential impact on the economy, but also because of our roles in bank supervision and regulation and in consumer protection.

From the standpoint of monetary policy, I do not consider it very likely that developments relating to subprime mortgages will have a big effect on overall U.S. economic performance, although they do add to downside risk. The types of subprime loans of greatest concern are variable-rate mortgages. Delinquency rates on these loans have risen sharply since the middle of last year—they are now nearly 12 percent—and there are indications that lenders are tightening credit standards for these borrowers. Looking more broadly across all types of mortgages, however, delinquency rates have remained low; this includes prime borrowers with fixed-rate and variable rate mortgages and even subprime borrowers with fixed-rate loans. Tighter credit to the subprime sector and foreclosures on existing properties have the potential to deepen the housing downturn. I am nonetheless optimistic that spillovers from this sector will be limited, because these mortgages represent only a small part of the overall outstanding mortgage stock.

The bottom line for housing is that it has had a significant depressing effect on real GDP growth over the past year. While I wouldn't want to bet on a sizable upswing, I also wouldn't be surprised to see it begin to stabilize late this year or next. Furthermore, if and when it does stabilize, it could contribute to a pickup in overall growth in the future, as the negative force of its contraction turns neutral.

To sum up the story on output, real GDP appears to have advanced at a modest rate in the first half of this year. My best guess is that the pace will pick up a bit in 2007 to a rate just below potential, as housing's negative effect eases up enough to offset the expected modest slowdowns in consumption and exports. As I've indicated, these crosscurrents may play out in unexpected ways, entailing both upside and downside risks, and they will bear careful watching.

Indeed, careful watching will be required even if the scenario for economic activity that I see as the best guess and the best hope comes through. The reason is that a key part of the desired adjustment path would involve the emergence of enough slack in labor markets to counteract inflationary pressures. The latest labor market data show payroll employment growing steadily and at a robust pace. Moreover, the unemployment rate has, somewhat surprisingly, declined by half a percentage point over the past year and a half and now stands at 4½ percent; that rate may represent a degree of tightness in the labor market. If labor markets are indeed on the tight side, and if they remain there, then there may be reason for concern about the risk of building inflationary pressures.

This situation highlights a puzzle I have discussed before: Why has the labor market continued to be so strong, even while economic activity has moderated? Let me briefly outline some possible explanations, beginning with the more worrisome ones. One such explanation is that goods markets could be stronger than we think. This is a possibility because an alternative measure of real activity—real income—is considerably stronger than our standard measure of real GDP—which we normally measure on the output side. So, it's possible, but by no means certain, that real GDP could be revised up in future benchmark revisions, meaning that both labor and product markets actually might contain inflationary pressures at present.

Second, a number of experts are now arguing that trend productivity growth may have slowed a bit recently,4 which might mean that the growth of potential output is lower than commonly assumed. Indeed, productivity has been surprisingly weak over the past year. Of course, discerning the extent to which this development reflects a short-lived, cyclical phenomenon, a downshift in the trend rate or both, is neither obvious nor straightforward. Those who believe that trend productivity growth has slowed a bit point to the slowdown in the first half of this decade in both the pace of productivity growth in the IT sector and the pace of investment in equipment and software, two factors that drove the productivity boom that began in the mid-1990s.

Although this argument may well be correct, it seems likely to me that the recent decline in the productivity data mainly reflects cyclical factors; in other words, it is likely due to labor hoarding and lags in the adjustment of employment to output—common phenomena in periods when economic activity decelerates. Interestingly, most of the recent slowdown in labor productivity growth can be accounted for by such lags in just one sector—residential construction. Although this sector has experienced huge drops in spending, employment has been remarkably well sustained. Going forward, as the adjustment lags work themselves out, residential construction employment may post significant declines and productivity in that sector and the economy as a whole may rebound. The possibility of long lags in the adjustment of employment to economic activity is a benign explanation for the puzzle.

Another benign possibility is that labor markets may not actually be particularly tight. There are a variety of ways to estimate conditions in the labor market, and some of these don't suggest much in the way of inflationary pressures. For example, the Conference Board index of job market perceptions, which is based on a survey of households, suggests that labor markets are only very slightly on the tight side. Moreover, if labor markets were tight, this could be expected to show up in robust growth of labor compensation. Instead, some of the data present a different picture: for example, the employment cost index shows remarkably restrained increases of only a little more than 3 percent over the past year.

At this point, I am not inclined to discount heavily these benign explanations. Looking at the price inflation data over the past year or so, signs of improvement are evident. Over the past twelve months, our main measure of consumer inflation—the price index for personal consumption expenditures excluding food and energy, or the core PCE price index—has increased by just under 2 percent. Just a few months ago, the twelve-month change was quite a bit higher, at nearly 2½ percent.

Moreover, I expect to see some further improvement in core inflation over the next year or two. First, this should occur as the economy develops some slack in response to real growth that is modestly below the potential rate. Second, inflation may have been elevated partly because of some transitory factors that may unwind over the next year or so. One of those transitory factors is oil prices. Although core inflation, by definition, excludes energy prices, they still may affect it to the extent that they are passed through to the prices of other goods and services. While oil prices have risen recently, they are still below their peaks of mid-2006. Over the two and a half years before that, energy prices more than doubled, and this probably put some upward pressure on core inflation. However, the effects of energy price changes on inflation are inherently temporary, and these upward pressures are likely to dissipate in 2007, even if energy prices remain at their current levels.

Another transitory factor is upward pressures on rents, including imputed rents on owner-occupied housing that enter importantly into the calculation of the price of housing services and, therefore, consumer inflation. Over the last year, rents have been rising at an unusually rapid rate. But if rents adjust to more normal levels relative to house prices, these increases will taper off, also damping inflation.

That said, the risks to inflation are also significant. One I have already mentioned is the possibility that structural productivity growth has slowed, which could add to cost pressures. While cyclical swings in productivity are not generally passed on to product prices, a decline in structural productivity growth might escalate inflation pressures. Another risk is possible slippage in the market's perception of our inflation objective. Although inflation compensation over the next five years, as measured in Treasury markets, has been essentially unchanged recently, longer-run inflation compensation rose modestly, along with the rise in long-term rates that I discussed earlier. My guess is that this increase largely reflects an elevation in inflation risk premiums or the influence of some idiosyncratic factors affecting the demand for Treasury debt, rather than an increase in long-run inflation expectations. I base this conclusion on the fact that longer-run inflation compensation also ticked up in the United Kingdom, a country where inflation expectations have been remarkably well anchored over the past decade and where inflation has been trending downward. The fact that longer-run inflation compensation rose in both countries, despite their different monetary policy regimes, suggests that a common explanation is needed, rather than one specific to the U.S. This result suggests that inflation expectations in the U.S. continue to be well anchored as they have been for at least the past ten years or so, as the Fed has established its credibility with the public about both its commitment to and its competence in keeping inflation at low and stable rates.5

Turning to monetary policy, I hope I've made it clear that—based on what we know now—I think the current stance of policy is likely to foster sustainable growth with a gradual ebbing of inflationary pressures. It has been heartening to see core consumer inflation edging down in recent months. However, as the most recent statement noted, "a sustained moderation in inflation pressures has yet to be convincingly demonstrated." Moreover, upside risks to inflation continue to be present, given the possibility that labor markets are somewhat tight. I believe it is important to be particularly attentive to these risks not only because price stability is desirable in its own right, but also because a credible commitment to keeping inflation low and stable is necessary to ensure that inflation expectations remain well-anchored. At the same time, we must be careful not to pose unnecessary risks to continued expansion.

An "asymmetric policy tilt" seems appropriate given the upside risks to inflation. However, it is also essential that policy retain considerable flexibility in responding to emerging data. Last week's FOMC statement thus continued to emphasize that "Future policy adjustments will depend on the evolution of the outlook for both inflation and economic growth, as implied by incoming information."

1. See also Eric Swanson, "What We Do and Don't Know about the Term Premium," FRBSF Economic Letter, forthcoming.

2. There is some research into why risk might be underpriced, but so far, the answers remain tentative. Some have pointed to the greater role of investment managers in this more deregulated, competitive environment. These managers may have incentives to herd with other investment managers in order not to underperform their peers, and they may also have incentives to take more "tail" risks, in cases where compensation is weighted more towards achieving positive returns, without sufficient regard for low probability negative returns.

3. See Glenn Rudebusch, Brian Sack, and Eric Swanson. 2007. "Macroeconomic Implications of Changes in the Term Premium," Federal Reserve Bank of St. Louis, Review, July/August, 89(4), pp. 241-269. http://research.stlouisfed.org/publications/review/07/07/Rudebusch.pdf

4. Stephen D. Oliner, Daniel E. Sichel, and Kevin J. Stiroh, "Explaining a Productive Decade," Brookings Papers on Economic Activity (March 29-30, 2007) http://www.brookings.edu/es/commentary/journals/bpea_macro/forum/200703oliner.pdf; Dale W. Jorgenson, Mun S. Ho, and Kevin J. Stiroh, "A Retrospective Look at the U.S. Productivity Growth Resurgence," unpublished paper, 2007; John Fernald, David Thipphavong, and Bharat Trehan, "Will Fast Productivity Growth Persist?" FRBSF Economic Letter, 2007-09, http://www.frbsf.org/publications/economics/letter/2007/el2007-09.html.

5. See Bharat Trehan and Jason Tjosvold, "Inflation Targets and Inflation Expectations: Some Evidence from the Recent Oil Shocks," FRBSF Economic Letter, 2006-22, September 1, 2006, http://www.frbsf.org/publications/economics/letter/2006/el2006-22.html. For a discussion of related issues, see John Williams, "Inflation Persistence in an Era of Well-Anchored Inflation Expectations," FRBSF Economic Letter, 2006-27, October 13, 2006, http://www.frbsf.org/publications/economics/letter/2006/el2007-27.html.

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위고비에 도전한 새 비만약 '에페' 가격은? [서울=뉴스핌] 김신영 기자 = 한미약품의 국산 비만 신약 '에페'가 위고비와 마운자로가 86%를 장악한 국내 비만치료제 시장에 뛰어든다. 후발주자인 만큼 자체 생산을 통한 가격 경쟁력과 국내 환자 임상 데이터, 기존 병·의원 영업망을 앞세워 선발 제품 중심의 처방 시장을 파고든다는 전략이다. 관건은 가격 이외의 경쟁력을 실제 처방 전환으로 연결할 수 있느냐다. 위고비와 마운자로는 글로벌 시장에서 이미 높은 인지도와 장기간의 처방 경험을 쌓은 데다 대표 임상에서 높은 체중 감량 효과를 제시했다. 에페가 연매출 1000억원 목표를 달성하려면 가격에 민감한 신규 수요를 확보하는 동시에 기존 GLP-1 치료제 사용자의 선택까지 끌어와야 한다. 17일 제약·바이오업계에 따르면 한미약품은 오는 10월 식품의약품안전처 품목허가를 목표로 에페(성분명 에페글레나타이드) 출시를 준비하고 있다. 허가 이후 연내 출시가 목표다. 한미약품 본사 전경 [사진=한미약품] ◆ 가격 경쟁력 갖췄지만…출시 이후 기존 제품 인하 변수 에페는 한미약품이 자체 개발한 주 1회 투여 글루카곤 유사 펩타이드(GLP-1) 계열 비만치료제다. 약물이 체내에서 오래 작용하도록 한 한미약품의 지속형 플랫폼 기술 '랩스커버리'가 적용됐다. 에페가 진입할 시장은 이미 선발주자 중심으로 2강 구도가 형성돼 있다. 의약품 시장조사기관 아이큐비아에 따르면 국내 비만치료제 시장은 2024년 2426억원에서 지난해 8195억원으로 1년 만에 3배 이상 확대됐다. 이 중 위고비와 마운자로 판매액은 각각 4833억원, 2209억원으로 두 제품이 전체 시장의 약 86%를 차지했다. 후발주자인 에페가 내세운 무기는 가격이다. 한미약품은 최종 공급가를 공개하지 않았지만 업계와 증권가에서는 4주 투약 기준 10만원대 가격이 거론된다. 현재 위고비의 시작용량인 0.25㎎의 4주분 공급가는 21만6000원, 마운자로의 시작용량인 2.5㎎은 27만8000원 수준이다. 한미약품이 가격 경쟁력을 확보할 수 있는 배경에는 자체 생산체제가 있다. 회사는 경기도 평택 바이오플랜트에서 에페를 직접 생산한다. 외부 생산 의존도를 낮춰 공급 안정성을 높이는 동시에 가격을 낮추겠다는 구상이다. 하지만 가격만으로 선발주자의 벽을 넘을 수 있을지는 미지수다. 국내에서 가장 먼저 출시된 비만치료제인 위고비는 마운자로의 국내 출시를 앞둔 지난해 용량별 차등가격제를 도입하면서 시작용량 공급가를 기존 37만2000원에서 21만6000원으로 약 42% 낮췄다. 경쟁 제품 등장에 맞춰 선발주자가 가격을 조정한 전례가 있는 만큼 에페 출시 이후 추가 가격 경쟁이 벌어질 가능성도 제기된다. 비만치료제의 핵심 경쟁력은 체중 감량 효과다. 한미약품이 공개한 에페 임상 3상 40주차 중간 결과에서 평균 체중 감소율은 9.75%였다. 체중이 5% 이상 감소한 환자는 79.42%, 10% 이상은 49.46%, 15% 이상은 19.86%였다. 선발 제품들은 글로벌 임상에서 더 높은 체중 감소율을 제시했다. 위고비는 비만 또는 과체중 성인 1961명을 대상으로 한 STEP 1 임상에서 68주 투여 후 평균 체중이 14.9% 감소했다. 체중이 5% 이상 줄어든 환자는 86.4%, 10% 이상은 69.1%, 15% 이상은 50.5%였다. 마운자로는 비만 또는 과체중 성인 2539명을 대상으로 한 'SURMOUNT-1' 임상에서 72주 후 평균 체중 감소율이 5mg 투여군 15.0%, 10mg 19.5%, 15mg 20.9%로 나타났다. 15mg 투여군에서는 70.6%가 체중을 15% 이상 줄였고, 56.7%는 20% 이상 감량했다. 다만 에페와 위고비, 마운자로의 임상은 투약 기간과 대상 환자, 용량과 시험 설계 등이 달라 체중 감소율을 단순 비교해 우열을 판단하기에 한계가 있다. 현재 공개된 에페의 임상 수치는 40주차 3상 중간 결과다. 한미약품 비만 신약 '에페' 로고 [사진=한미약품] ◆ 국내 환자 448명 임상으로 차별화, 브랜드·시장 경험은 숙제 이에 한미약품이 강조하는 에페의 차별점은 국내 환자를 대상으로 직접 확보한 임상 데이터다. 에페 임상 3상은 국내 성인 비만 환자 448명을 대상으로 실시했다. 위고비 역시 한국인을 포함한 아시아 환자 대상 임상을 진행했지만 에페는 3상 전체를 국내 비만 환자로 구성했다. 한미약품은 국내 환자로 구성된 임상을 통해 한국 진료현장에서 참고할 수 있는 데이터를 확보했다는 점을 차별화 요소로 내세운다. 다만 국내 환자 대상 임상이라는 사실 자체가 기존 치료제보다 높은 효능이나 안전성을 의미하는 것은 아니다. 임상에서 체질량지수(BMI) 30㎏/㎡ 미만 여성 환자의 평균 체중은 12.20% 감소했다. 한미약품은 이를 토대로 고도비만 환자뿐 아니라, 비만도가 낮거나 장기적인 체중 관리가 필요한 환자까지 처방 수요를 넓힐 수 있을 것으로 보고 있다. 한미약품은 에페가 GLP-1 비만치료제의 대표적인 부작용인 구역과 구토 등 위장관계 이상반응이 기존 제품 대비 낮다는 점도 내세우고 있다. 구역과 구토는 비만치료제의 투약을 중단하게 하는 요인으로 거론된다. 그러나 브랜드 인지도와 시장 경험에 있어서는 선발주자의 우위가 뚜렷하다. 위고비와 마운자로는 각각 노보 노디스크와 일라이 릴리라는 글로벌 대형 제약사의 제품으로, 해외에서 이미 대규모 판매와 처방 경험을 축적했다. 환자들의 실제 사용 경험과 장기 데이터가 쌓였다는 점도 후발주자인 에페가 단기간에 따라잡기 어려운 부분이다. 반면 한미약품은 국내 병·의원을 대상으로 구축한 영업망과 자체 생산능력을 갖추고 있다. 기존 영업망을 치료제 처방으로 연결할 수 있느냐가 후발주자의 한계를 극복할 변수가 될 것이라는 평가가 나온다. 한미약품은 에페를 연 매출 1000억원 이상 품목으로 육성한다는 목표를 세웠다. 목표 달성을 위해서는 가격 경쟁력 등 회사가 내세운 강점을 처방 확대로 연결할 수 있어야 한다.  한 업계 관계자는 "에페는 가격과 국내 환자 대상 임상 데이터에서 차별화 요소가 있지만 위고비와 마운자로는 높은 인지도와 처방 경험을 확보한 제품"이라며 "후발주자인 만큼 실제 진료 현장에서 의사와 환자의 선택을 얼마나 바꿀 수 있느냐가 시장 안착의 관건"이라고 봤다. sykim@newspim.com 2026-09-17 15:33
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李, 일정 최소화 '18일 회견' 준비 몰두 [서울=뉴스핌] 김미경 기자 = 이재명 대통령이 18일 기자회견을 하루 앞둔 17일 공식 일정을 최소화하고 회견 준비에 몰두했다. 이 대통령은 지난 14일부터 3일간 중앙아시아 5개국 정상과 연쇄 회담을 하고 1차 한-중앙아시아 정상회의를 주재하며 외교 일정으로 숨가쁘게 지냈다.  이 대통령이 기자회견 일정을 18일로 정한 것도 외교 일정을 모두 마무리하고 하루 정도 준비하는 시간이 필요하다는 판단을 한 것으로 보인다.  이 대통령은 이날 통상 목요일에 열던 수석보좌관회의도 없이 파티 비롤 국제에너지기구(IEA) 사무총장을 접견하는 일정만 소화한다.  이재명 대통령이 취임 1주녁 기자회견에서 주택공급을 위해 재건축·재개발도 속도를 내야한다고 말했다. [사진=청와대]  ◆청와대 "국민이 궁금한 국정 현안, 진솔하게 소통할 것" 이 대통령은 비롤 사무총장 접견 외 나머지 시간은 회견 준비에 쓸 것으로 예상된다. 이 대통령은 참모들에게서 분야별 핵심 쟁점과 추진 방향을 보고받고 예상 질문을 추려 답변을 거듭 다듬는 것으로 알려졌다. 회견은 18일 오전 10시 청와대 영빈관에서 열린다. 모두발언과 질의응답, 마무리 발언을 합쳐 90분가량 진행한다는 계획이다. 기자회견에는 내·외신 기자 150여 명이 참석한다. 질의응답은 정치·외교와 정책·경제 두 분야로 나눠 주제 제한 없이 진행하고 실시간 국민 댓글도 소개한다. 청와대는 회견 제목을 수식어 없이 '이재명 대통령 기자회견'으로 정했다. 회견장 배경막에는 '국민의 뜻, 국민의 삶, 더 살피겠습니다'라는 문구를 건다. 성기홍 청와대 홍보소통수석은 지난 15일 브리핑에서 "대통령의 확고한 개혁 의지와 민생 최우선 국정 기조, 더 단단한 국민 통합의 메시지를 전하는 자리가 될 것"이라고 했다. 이어 "국민이 궁금해하고 듣고 싶어 하는 국정 현안을 진솔하고 충실하게 소통하려 한다"고 설명했다. [서울=뉴스핌] 이건주 기자 = 8일 오전 서울 중구 하나은행 딜링룸에서 이재명 대통령 취임 1주년 기자회견 '대체불가 대한민국'이 생중계되고 있다. 2026.06.08 kunjoo@newspim.com ◆연임·공소취소·파병 정치 현안에 부동산·증시 민생 현안 산적  회견의 관심은 산적한 현안에 이 대통령이 과연 명확한 입장을 밝힐 것인지다. 특히 공소 취소와 연임 헌법 개정(개헌) 논란은 피할 수 없는 질문이다. 집권 여당인 더불어민주당은 '조작기소 특검법안'을 9월 중 처리하겠다고 예고했다. 특검에 공소취소 권한을 줄지가 핵심 쟁점이다. 이 대통령 사건 공소 취소를 앞장서 주장했던 김승원 의원이 법무부 장관 후보자로 지명됐고 민주당 주도로 국회 인사청문 경과보고서가 채택됨에 따라 야권의 공세는 더 거세졌다. 인사 검증 문제에 대한 언론의 질의도 예상된다. 용혜인 전 성평등가족부 장관 후보자는 자진사퇴했고 김승원 후보자는 '식약처 청탁 의혹'에 휩싸였다. 미국 요청에 따른 호르무즈 해협 파병 검토와 대미 투자 협상 관련 질문도 이 대통령에게는 고난도 문제다.  민생 현안으로는 부동산이 첫손에 꼽힌다. 정부는 취임 후 8·13 대책을 포함해 6차례 부동산 대책을 내놨다. 하지만 한국부동산원 집계에 따르면 서울 아파트 주간 매매 가격이 지난해 2월 첫째 주부터 83주 연속 올랐다. 문재인 정부 시절 세운 최장 기록(85주)에 바짝 다가섰다. 강남 3구 집값은 약세로 돌아섰지만 수도권 중저가 아파트값이 오르고 전세 매물 품귀와 월세 상승이 이어지고 있다. 부동산 정책 효과에 대한 논란이 적지 않다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆이 대통령 "임기는 헌법상 명확하게 제한"…이번엔 어떤 답 낼까 이 대통령이 앞서 일부 현안에 짧게 입장을 밝히기는 했지만 대체로 원론적 언급에 그친 경우가 많았다.  연임 개헌 논란을 두고는 프랑스 국빈방문 중이던 지난 9일(현지시간) 파리 동포 오찬간담회에서 "(대통령) 임기는 헌법상 명확하게 제한돼 있다"고 했다. 취임 초 해외 순방을 자주 다니는 이유를 설명하는 차원의 언급이었지만 연임 논란을 의식한 우회적 입장 표명이라는 해석이다.  공소 취소와 관련해서는 지난 6월 8일 진행한 취임 1주년 회견에서 "(조작기소 여부의) 진상 규명은 해야 한다"는 원론적 답변을 내놨다. 이 대통령은 당시 공소 취소 특검에 대한 질문을 받고 "결론적으로 법과 상식대로 하면 된다"며 "최소한의 진상규명을 해야 한다"고 했다. 이 대통령은 "뭔가 문제는 있어 보인다. 주관적 판단은 있지만 객관적으로도 문제가 있어 보이는 것이 꽤 많다"며 "잘못된 게 있으면 바로 잡고 없으면 그냥 놔두면 된다. 잘못됐으면 취소하고 잘못된 게 아니면 놔두는 것"이라고 했다. 사실상 공소가 잘못됐으면 바로 잡아야 한다는 취지의 설명이었다.  ◆여권에서도 "공소취소·연임 명확한 입장 내야" 목소리 강해   야권뿐 아니라 여권에서도 이 대통령이 민감한 현안에 대해 명확한 입장 표명을 해야 한다는 목소리가 강하다. 장동혁 국민의힘 대표는 이날 최고위원회의에서 "기자회견이 의미가 있으려면 그동안의 오만과 무능부터 국민에게 사과해야 한다"며 "부동산과 이란 파병 문제 등 모든 정책에서 국정 기조 대전환을 선언하고 국민이 납득할 분명한 답을 내놓길 바란다"고 요구했다. 한병도 민주당 원내대표는 정책조정회의에서 "기자회견은 국민 목소리를 경청하고 국정 현안을 두고 진솔한 대화를 나누는 소통의 장이 될 것"이라고 강조했다.  이광재 민주당 의원은 "공소 취소는 정무적이고 정치적인 문제이니 대통령이 언급할 것으로 본다"고 했다. 여권의 한 중진 의원은 "대통령이 연임 개헌이나 공소 취소와 관련해 명확한 입장을 내놓지 않는다면 향후 국정 운영이 쉽지 않을 것"이라고 우려했다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆9주 연속 지지율 하락…추석 전 기자회견, 반등 할까  이번 기자회견은 추석 연휴를 앞두고 열리는 만큼 지지율 반등의 분수령으로 꼽힌다. 여론조사 전문기관 리얼미터가 14일 공개한 9월 2주차 주간동향(에너지경제신문 의뢰, 7~11일, 무선 자동응답 방식 조사, 표본오차는 95% 신뢰수준에 ±2.0%포인트, 중앙선거여론조사심의위원회 홈페이지 참조)을 살펴보면 이 대통령의 국정수행 긍정평가는 9주 연속 하락해 취임 후 최저치인 33.8%였다. 부정평가는 63.3%로 처음 60%대에 올라섰다. 리얼미터는 외교 행보에도 개각 인선 논란과 호르무즈 파병 검토, 부동산 정책 불확실성이 겹친 데다 진보층과 20대 이탈이 더해진 것을 하락 주요 원인으로 분석했다.  한국갤럽이 17일 발표한 '2026 대한민국 신뢰도 조사'(시사IN 의뢰, 6~8일, 유선전화와 휴대전화 무작위 전화걸기 전화면접조사)에서는 이 대통령이 정치인 중 2위로 내려앉았다. 이 대통령은 2021년 이후 해당 조사에서 줄곧 가장 신뢰하는 정치인 1위였다. 올해 조사에서는 한동훈 무소속 의원에게 1위를 내줬다.  이 대통령에 대한 신뢰도 조사에서는 '신뢰한다' 35.9%, '불신한다' 50.4%였다. 지난해 조사에서는 이 대통령을 신뢰한다는 응답이 51.2%, 불신한다는 응답이 34.1%였다. 신뢰와 불신의 국민 평가가 1년 만에 뒤집어졌다.  the13ook@newspim.com 2026-09-17 14:37
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