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Remarks by Charles L. Evans
President and Chief Executive Officer
Federal Reserve Bank of Chicago


University of Chicago Graduate School of Business
Chicago, IL

October 22, 2007

Current Economic Outlook*

Introduction

It really is a pleasure for me to be here at an event cosponsored by the University of Chicago's Graduate School of Business and the Chicago Council on Global Affairs. The Federal Reserve Bank of Chicago has benefited greatly from so many of the relationships it has established over the years with the GSB and the Council. Working together with the academic, business, and policy communities of this city, we have been able to address important economic issues at forums like this one. My being here tonight is an excellent example of just that, and I am delighted to have this venue serve as my first public speaking event since becoming President and CEO of the Chicago Fed on September 1.

I would like to emphasize that my comments today are my views and not necessarily those of my colleagues on the Federal Open Market Committee.

Though I have been President for only two months, I have had the remarkably useful experience of attending FOMC meetings since 1995 — first as a senior staffer and since 2003 as the Bank's Research Director. Over these past 12 years, I have observed the Committee make policy during a variety of interesting and challenging economic and financial periods. And most of my research career has involved studying monetary policy decision-making and its effects on the economy. Indeed, I first met then Professor Ben Bernanke at a research conference where we both presented papers on monetary economics. It shouldn't come as a surprise to anyone that I expect to draw on these experiences in my participation at FOMC meetings.

Since this is my first speech as President, I will first take some time to provide background on how I approach the analysis of monetary policy decision-making. I will then discuss current economic conditions.

Putting the Current Policy Decision in a Broader Context

Over the past 10 years we have witnessed a number of very different kinds of developments and shocks to the economy — the acceleration in worker productivity, the emerging market debt crises in 1997-98, the high-tech boom and bust at the turn of the century, and the tragic events of September 11, to name a few. Seeing the Committee make decisions when faced with such events emphasized to me that no matter how unique or uncertain the situation may seem, it is important to view the current policy decision in the broader context of our efforts to achieve maximum employment and price stability. These, of course, are the dual mandates of the Federal Reserve when conducting monetary policy for the United States.

Let me take a few moments to discuss how I go about putting policy decisions into this broader perspective. Specifically, I'd like to talk about three kinds of considerations that I think are always important for coming to a sound policy decision. The first is the most obvious: our need to assess the general condition of the economy—both in terms of its underlying structure and its current cyclical performance. Such an assessment helps us to understand how the particular events we are experiencing will work their way through the economic system to influence growth and inflation over the coming quarters and years. The second set of considerations concerns the stance of monetary policy. Specifically, it's always important to ask where the federal funds rate stands relative to some concept of a neutral rate and how the resulting degree of accommodation or restriction will influence the achievement of our dual mandate. The final category of considerations has to do with the degree of uncertainty that we face with regard to both the state of the economy and the effects of policy. At times we may need to adopt a risk management approach to policy—that is, adjust the stance of policy to guard against the risk of events that may not be in our baseline projection but, if they did occur, would present an especially notable threat to sustainable growth or price stability. Often such policy adjustments can be described as pre-emptive, in the sense that they reduce the odds of the more adverse outcome occurring.

1. The Structure of the Economy

The first issue deals with initial economic conditions and the dynamic structure of the U.S. economy. When the economic climate shifts and policy is adjusted, the ultimate effect on output and inflation depends on how various economic players and markets work and interact with one another, how prices adjust to re-direct resources, the rate at which technology progresses, and a myriad of other structural characteristics of the economy. The influence of an unexpected shock also depends on how shorter-term cyclical conditions compare with our policy goals; that is, how much resource slack is present in the economy and where the outlook for inflation is relative to price stability. Our broader policy analysis has to account for both the structural and cyclical factors.

One longer-run structural feature to consider is the fact that since the mid-1980s fluctuations in aggregate output have been a good deal smaller than they were earlier in the post-war period. Recessions have been less severe, there has been less commonality in fluctuations across industries, and inflation has been lower and less volatile. The U.S. has been in what economists refer to as "The Great Moderation." We do not have a complete explanation for what caused the Great Moderation. Some research points to smaller shocks, suggesting the U.S. economy has enjoyed a bit of good fortune. Other studies emphasize improved control over inventories, and some analyses give a role to financial market innovations that allow for more efficient allocation of financing and better risk sharing. These and other such structural developments suggest that the economy's natural shock absorbers may operate better today, supporting the conclusion that the U.S. economy has become more resilient. Accordingly, the outlook on which we base our policy decision should account for the likelihood that a given economic event might result in smaller and less persistent fluctuations in output and inflation.

There also is an interplay between the reaction of policy to events, the increased resiliency of the economy, and where we stand relative to our policy goals. Let me give you a couple of historical examples. Think about the oil shocks in the 1970s. These hit when inflation pressures already had been rising. Furthermore, around the same time there had been a decline in the rate of sustainable economic growth. This change and its inflationary implications were not well recognized at the time. Looking back, we think now that part of the slower growth reflected inflexibilities that made it difficult for many industries to adjust to higher energy prices. The ultimate outcome was a deep recession in 1973-75 and soaring inflation. Eventually, the Volcker Fed had to implement highly restrictive and costly policies to bring inflation down. In contrast, when oil prices began increasing in 2004, core PCE inflation was just 1-1/2 percent, the underlying trend in productivity was relatively solid, and the energy efficiency of the economy was much better than during the 1970s. One reason the economy performed better is that the shock was smaller. But it also is the case that the shock hit a more flexible economy that was performing well. Together, these meant that overall growth was better maintained and only a modest policy adjustment was necessary to check the pass-through of energy costs to the trend in inflation.

2. Where Policy Stands Relative to a Neutral Rate

Now let's turn to the second issue — assessing the stance of policy. At any particular FOMC meeting, after reviewing the economic and financial situation, the discussion turns to the policy decision. For me, this requires focusing on longer-run benchmarks, in particular, where the current fed funds rate is relative to a conceptual, neutral setting for policy. By a neutral funds rate, I mean the rate that is consistent with an economy operating along its potential growth path and with stable inflation. I will readily admit that there is a great deal of uncertainty about measuring this neutral rate. Still, with appropriate caveats, the neutral fed funds rate is a useful benchmark. One reason why John Taylor's research on monetary policy rules has been so useful is because the Taylor rule casts the prescriptions for the funds rate against such a benchmark. Rates above neutral tend to restrict aggregate demand, and rates below neutral are accommodative. At any point in time, if we simply look at the decision to raise, lower, or leave unchanged the fed funds rate, then we lose perspective on the overall stance of policy. This is a relatively obvious point, but one that bears emphasizing: Hypothetically, when policymakers raise the funds rate and it remains below the neutral rate, then, on net, policy still is accommodative. Indeed, this was the case in late 2004 and 2005.

There are a number of determinants of the neutral rate. One important determinant is productivity. With higher productivity growth, the return to investment is higher, and a higher neutral interest rate is necessary to equilibrate capital market flows and aggregate demand and supply. Another key determinant is the expected inflation rate. In order to induce savers to forego consumption, they must be compensated for any loss in purchasing power over time due to rising prices. So a higher expected inflation rate translates into a higher neutral federal funds rate.

This brief description is obviously not complete. First, we do not have an exact estimate of the neutral rate. It depends on factors that we cannot observe directly — for example, the structural long-run trend in the rate of productivity growth and inflation expectations. We thus turn to statistical estimates and indirect measures, which by their very nature are imprecise. Second, the neutral rate can change over time as its components change, and it is often difficult to ascertain these movements until well after the fact. Consider, for example, how hard it was to discern the permanence of the productivity increase in the second half of the 1990s. Third, the degree of accommodation represented by the gap between the actual and neutral funds rate is only one factor affecting the amount of liquidity that is ultimately influencing economic activity and inflation. Other financial circumstances can work to offset or exaggerate the impulse from policy, and these can change dramatically over time—as we have witnessed recently with the swing in credit market conditions. And, as if this wasn’t tough enough, quantifying the net impact of financial conditions on the economy is technically challenging.

3. Acknowledging Uncertainties

These caveats about the neutral fed funds rate and the stance of policy also relate to the third element of my broader view towards policy; that is, the importance of recognizing and respecting the uncertainty and related risks we face when making policy decisions. This uncertainty is large. Indeed, it is somewhat amusing how often we are tempted to say that things are more uncertain today than they usually are. Well, if we think this so often, it can't be very unusual. A myriad of factors can and do regularly generate substantial uncertainties about the outlook for the economy — think of the list I gave earlier: the productivity acceleration, the emerging market debt crisis, the high-tech boom and bust, and September 11 and its aftermath. So a key aspect of policymaking is understanding when uncertainties are especially large, identifying associated risks to the forecast, and assessing the implications of these risks for achieving price stability and maximum sustainable growth.

Some risks relate to possible events or extreme macroeconomic outcomes that are not very likely to occur, but whose cost in terms of output or inflation could be quite large. In such cases, it is prudent to adjust policy to be more or less accommodative than we otherwise would as insurance against the highly adverse outcome. These are the risk management or pre-emptive views of policy I mentioned earlier, and they are a common component in central bankers' strategies. But if the extreme event does not occur or its influence subsides quickly, then it is incumbent upon policymakers to recalibrate policy — and to do so from a baseline that accounts for how the additional insurance put into the system affects the outlook for growth and inflation.

A different, and more typical, set of risks relates to where our forecast stands relative to our longer-run policy goals — for example, whether growth will be significantly above or below its sustainable rate and whether inflation will be too high or too low. And it is interesting that we are finally operating in a world with two-sided inflation risks — we thought it was too high in early 2007 at 2-1/2 percent, but that it is was too low in 2003 when, according to the data published at the time, it fell below 1 percent.

Background for the Current Outlook

Now that I have provided some background for how I approach monetary policy issues, I will turn to the current outlook and policy situation. In doing so, I will discuss it in terms of the structural and cyclical characteristics of the economy, the stance of policy relative to neutrality, and the uncertainties we are facing in the policy decision.

A good place to start the discussion is with the situation at midyear before the recent disruptions in credit markets. At the Chicago Fed, we expected that the contraction in residential construction would likely restrain overall activity for a while longer, but that this restraint would abate as we moved through next year. Indeed, outside of housing, the economy has been performing fairly well: Over the previous year and a half, declines in residential investment reduced real GDP growth by about 3/4 percentage point, but the rest of the economy increased at a solid 3-1/4 percent rate. Overall, we were expecting average GDP growth in the second half of 2007 to be somewhat below potential — which we then thought was just slightly under 3 percent — but that growth would return to potential as we moved through 2008.

Our June projection looked for the unemployment rate to rise from 4-1/2 to 4-3/4 percent by the end of 2008. Of course, 4-3/4 percent is a historically low value for the unemployment rate. This and other evidence suggested some risk of resource pressures showing through to inflation. Indeed, while core inflation had come down from early in the year, we were concerned that some of that drop might prove to be transitory. As a result, our June forecast was for core inflation to run around 2 percent — about the same as its pace over the previous year, but higher than the rate we had seen in the more recent months.

At the time, the funds rate was 5-1/4 percent, and market participants were expecting little change in the rate over the projection period. Back in June, a 5-1/4 percent funds rate probably was a bit above what I considered neutral. Although, given the caveats I discussed earlier, there was a healthy dose of uncertainly around this assessment. In my opinion, this restrictive stance for policy attempted to balance several factors. Importantly, financing conditions for most firms were still highly favorable. Notably, most risk premia remained quite low and many buyout deals were being done without typical loan covenants and other forms of credit protection. So there was a risk that these factors made overall financial conditions more accommodative than suggested by the funds rate alone. When combined with the risk to inflation from resource pressures, this suggested to me that a slightly restrictive funds rate was useful to mitigate potential inflationary risks.

However, as events unfolded in July, before the August turmoil in the credit markets, new information pointed to a reduction in the neutral fed funds rate, which meant that the stance of policy had become more restrictive.

The first factor lowering the equilibrium funds rate had to do with information revealed with the annual revisions to the national income accounts that were released in late July. These revisions included lower estimates for GDP. These helped reduce uncertainty about an important question — namely, the possibility that there had been some decline in the underlying trend growth in productivity since the first half of the decade. This factor also tends to signal higher unit labor costs and inflationary pressures. However, on balance, we in Chicago were impressed that the improvements in core inflation that we had seen earlier in the year seemed to be more persistent than we had initially thought. This caused us to adjust down our forecast for inflation in 2008-09. The lower estimate for trend productivity growth and the lower inflation forecast both pointed to a somewhat lower neutral funds rate. Hence, these factors suggested that the stance of policy was more restrictive than I believed in June.

The Financial Turmoil of August

Then came the financial turmoil in August. In light of the substantial increase in default rates on sub-prime mortgages, market participants substantially reduced the perceived value of all kinds of debt instruments backed by subprime mortgages. The resulting losses on balance sheets greatly reduced the amount of leverage that could be supported by these assets, and a period of de-leveraging began. In addition, market participants began to question the value of other complex securities. And, in general, many borrowers had to turn to shorter-term financing as lenders were unwilling to commit funds at term because of uncertainty over the valuation of collateral, potential needs for liquidity, and counterparty risks. Liquidity became scarce — as evidenced, for example, by large increases in spreads between overnight and term financing rates.

It is important to remember, however, that many financial markets have continued functioning without any problems. Highly rated corporate borrowers have had little trouble issuing bonds at favorable rates, and banks continue to lend to sound businesses. Indeed, although the cost of funding to some borrowers might be higher, we have not heard widespread reports of businesses being unable to finance working capital or longer-run capital expenditures.

Nevertheless, financial conditions in private credit markets are clearly more restrictive than they were a couple of months ago. In my opinion, it was no longer appropriate for monetary policy to include a slight degree of policy restraint to lean against the risks posed by low risk-pricing in financial markets. Those risks had receded. And, importantly, they had done so against the backdrop of a more favorable inflation outlook and a lower neutral rate.

Uncertainty and Risk Management in the Current Environment

As I mentioned at the start of my talk, policymakers need to take account of the uncertainty that they face and tailor policy in a way to best manage the risks to sustainable growth and price stability imposed by those uncertainties.

The gyrations in financial markets add a number of uncertainties to the outlook. Currently, market participants are in the process of reassessing credit exposures and establishing new risk pricing standards. There is uncertainty regarding how long this process will last and where it might take us. Indeed, developments in the last week reinforce this. Many market participants did not have a good idea of the credit risk associated with the opaque assets that they had purchased. For example, some investors may have assumed that a triple-A tranche of a sub-prime mortgage-backed security carried little default risk. They now know this assumption was wrong. This affects both how investors value their own books and how they assess the repayment abilities of counterparties who have been holding such assets to finance future transactions. So firms must now sift through their books and reassess the risks associated with the securities they are holding. This process is not easy: In some cases the instruments are quite complex, making it hard to identify the riskiness of the actual cash flows supporting the securities.

Ultimately, with more diligent and improved risk assessments, price discovery will go forward. The market mechanism will produce new prices at which participants are willing to trade risky assets. Continued improvements in trading will occur, albeit at values that more appropriately reflect the underlying credit and counterparty risks. But what the path to this new risk pricing will look like is still uncertain.

Another uncertainty surrounds the impact of the change in credit conditions on real economic activity. Some firms likely are facing higher costs and less favorable terms. At least to date, however, we do not seem to be seeing an impact on capital spending. Similarly, consumer credit conditions have not changed much in response to the financial turmoil. But the demand for housing has been further reduced because the inability to securitize non-conforming mortgages has contributed to a large cutback in such originations, particularly for sub-prime loans.

To me, the uncertainties about how financial conditions might evolve and affect the real economy mean that risk management considerations have an important role in the current policy environment. The cutback in nonconforming mortgage originations and the continued high level of inventories of unsold homes will result in further weakness in housing markets. Under one scenario, the effects on overall growth will be fairly isolated to declines in residential construction — similar to our experience in 2006 and early 2007. However, there is a less benign possibility. Housing demand and prices could weaken a good deal more than we expect — either because a new shock hits the sector or because we have underestimated the weakness already in train. A more pronounced downturn could weigh more heavily on consumer spending. In addition, further delinquencies and foreclosures could add to the problems with mortgage-backed securities. This, in turn, could generate further adverse effects on financial conditions that support economic activity. Together, such events would pose a more serious downside risk to growth.

I want to emphasize that I do not see this extreme outcome as likely. But it is one of those high cost outcomes that we should guard against. The challenge is to calibrate the insurance in light of the lower probability of the spillover event occurring. Furthermore, if in fact the more likely scenario unfolds in which conditions improve and risks recede, then policy should be prepared to respond to any developments that threaten the inflation outlook.

Indeed, not all of the risks to the economic outlook are on the downside. The effects of financial difficulties on real activity are hard to predict. For example, recall 1998, when concerns about the fallout of the Russian default on other emerging market debt and the difficulties related to LTCM led to a freezing of activity in certain financial markets. Despite all of the concerns about how this might affect economic activity, in 1999 real GDP ended up growing 4.7 percent and significant resource pressures emerged.

Returning to the current situation, the process of assessing credit exposure appears to be well underway and a number of large financial institutions already have reported losses on their books. There is also some evidence suggesting that investors are more willing to differentiate between commercial paper issuers based on the quality of the underlying assets. Markets also have become somewhat more receptive to high-yield issues and to term lending. In addition, term premia in markets where liquidity was impaired have come down, though they remain above levels that prevailed in late July. There still is a way to go. Improvements are not uniform, and risks remain. However, markets are functioning better than they were two months ago.

The Outlook and the Policy Picture Going Forward

Putting all of this information together, our baseline forecast sees soft economic activity this fall; notably, it is likely that a further sharp decline in residential investment will weigh on the top-line growth numbers. But we see growth recovering next year and moving up to average close to potential later in 2008, which we at the Chicago Fed currently see as being somewhat above 2-1/2 percent. This lower potential number in part reflects an assumed trend in productivity growth that is slower than the trend we experienced over the 1995-2003 period. Nonetheless, the new productivity trend is still a healthy one by longer-term historical standards and, accordingly, should support income creation, job growth, and household and business spending. Solid demand for our exports should also be a plus for growth. Although we expect a small increase in the unemployment rate, labor markets in general should remain healthy.

Indeed, on balance, I would characterize the data we have received on the real economy since the last FOMC meeting as supporting our baseline forecast. True, housing markets have tumbled further — sales fell sharply in August, new construction dropped a good deal further in August and September, and prices have softened. But the rest of the economy appears to be moving forward. Sales at automotive dealers and other retailers posted good numbers (in real terms) in August and September, indicators point to further increases in business investment, and industrial production has continued to rise. Importantly, according to the revised data, nonfarm payrolls increased an average of about a 100,000 per month rate in August and September — a pace we think is in line with demographic trends and an economy growing at potential.

With regard to inflation, we do not see any large movement one way or the other from current levels of core price inflation. Here the risks seem two-sided. With no appreciable slack in resource markets, cost pressures from higher unit labor costs, energy, or import prices could show through to the top-line inflation numbers. However, weaker economic activity would tend to mitigate the potential for this.

The latest numbers on inflation have been positive. The 12-month change in core PCE prices remained at 1-3/4 percent in August. We do not have the PCE index for September yet, but the CPI data for September that were released last week showed a moderate increase in core prices. At present, my outlook is for core PCE inflation to be in the range of 1-1/2 to 2 percent in 2008-09. Relative to our outlook six months ago, this is a favorable development.

Conclusion

Looking ahead, we will need to monitor developments regarding the outlook for both growth and inflation quite carefully. We will have our eyes open for the downside risks that I mentioned earlier. Events also could transpire that cause us to boost our growth projection. In addition, we cannot afford to be lax on the inflation front. Although I am optimistic about the chances for further inflation improvements, I would see any increase in inflation or inflation expectations from their current levels as a serious concern.

Over time, the current set of uncertainties and risks will fade. However, others will take their place — some will appear to be new and unique, and some we will have faced before. In any event, my views on monetary policy will depend on my outlook for the economy, the risks and uncertainties embedded in the forecast, and how these relate to the achievement of the Federal Reserve's dual mandate for maximum sustainable growth and price stability.

*The views presented here are my own and not necessarily those of the Federal Open Market Committee or the Federal Reserve System.

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위고비에 도전한 새 비만약 '에페' 가격은? [서울=뉴스핌] 김신영 기자 = 한미약품의 국산 비만 신약 '에페'가 위고비와 마운자로가 86%를 장악한 국내 비만치료제 시장에 뛰어든다. 후발주자인 만큼 자체 생산을 통한 가격 경쟁력과 국내 환자 임상 데이터, 기존 병·의원 영업망을 앞세워 선발 제품 중심의 처방 시장을 파고든다는 전략이다. 관건은 가격 이외의 경쟁력을 실제 처방 전환으로 연결할 수 있느냐다. 위고비와 마운자로는 글로벌 시장에서 이미 높은 인지도와 장기간의 처방 경험을 쌓은 데다 대표 임상에서 높은 체중 감량 효과를 제시했다. 에페가 연매출 1000억원 목표를 달성하려면 가격에 민감한 신규 수요를 확보하는 동시에 기존 GLP-1 치료제 사용자의 선택까지 끌어와야 한다. 17일 제약·바이오업계에 따르면 한미약품은 오는 10월 식품의약품안전처 품목허가를 목표로 에페(성분명 에페글레나타이드) 출시를 준비하고 있다. 허가 이후 연내 출시가 목표다. 한미약품 본사 전경 [사진=한미약품] ◆ 가격 경쟁력 갖췄지만…출시 이후 기존 제품 인하 변수 에페는 한미약품이 자체 개발한 주 1회 투여 글루카곤 유사 펩타이드(GLP-1) 계열 비만치료제다. 약물이 체내에서 오래 작용하도록 한 한미약품의 지속형 플랫폼 기술 '랩스커버리'가 적용됐다. 에페가 진입할 시장은 이미 선발주자 중심으로 2강 구도가 형성돼 있다. 의약품 시장조사기관 아이큐비아에 따르면 국내 비만치료제 시장은 2024년 2426억원에서 지난해 8195억원으로 1년 만에 3배 이상 확대됐다. 이 중 위고비와 마운자로 판매액은 각각 4833억원, 2209억원으로 두 제품이 전체 시장의 약 86%를 차지했다. 후발주자인 에페가 내세운 무기는 가격이다. 한미약품은 최종 공급가를 공개하지 않았지만 업계와 증권가에서는 4주 투약 기준 10만원대 가격이 거론된다. 현재 위고비의 시작용량인 0.25㎎의 4주분 공급가는 21만6000원, 마운자로의 시작용량인 2.5㎎은 27만8000원 수준이다. 한미약품이 가격 경쟁력을 확보할 수 있는 배경에는 자체 생산체제가 있다. 회사는 경기도 평택 바이오플랜트에서 에페를 직접 생산한다. 외부 생산 의존도를 낮춰 공급 안정성을 높이는 동시에 가격을 낮추겠다는 구상이다. 하지만 가격만으로 선발주자의 벽을 넘을 수 있을지는 미지수다. 국내에서 가장 먼저 출시된 비만치료제인 위고비는 마운자로의 국내 출시를 앞둔 지난해 용량별 차등가격제를 도입하면서 시작용량 공급가를 기존 37만2000원에서 21만6000원으로 약 42% 낮췄다. 경쟁 제품 등장에 맞춰 선발주자가 가격을 조정한 전례가 있는 만큼 에페 출시 이후 추가 가격 경쟁이 벌어질 가능성도 제기된다. 비만치료제의 핵심 경쟁력은 체중 감량 효과다. 한미약품이 공개한 에페 임상 3상 40주차 중간 결과에서 평균 체중 감소율은 9.75%였다. 체중이 5% 이상 감소한 환자는 79.42%, 10% 이상은 49.46%, 15% 이상은 19.86%였다. 선발 제품들은 글로벌 임상에서 더 높은 체중 감소율을 제시했다. 위고비는 비만 또는 과체중 성인 1961명을 대상으로 한 STEP 1 임상에서 68주 투여 후 평균 체중이 14.9% 감소했다. 체중이 5% 이상 줄어든 환자는 86.4%, 10% 이상은 69.1%, 15% 이상은 50.5%였다. 마운자로는 비만 또는 과체중 성인 2539명을 대상으로 한 'SURMOUNT-1' 임상에서 72주 후 평균 체중 감소율이 5mg 투여군 15.0%, 10mg 19.5%, 15mg 20.9%로 나타났다. 15mg 투여군에서는 70.6%가 체중을 15% 이상 줄였고, 56.7%는 20% 이상 감량했다. 다만 에페와 위고비, 마운자로의 임상은 투약 기간과 대상 환자, 용량과 시험 설계 등이 달라 체중 감소율을 단순 비교해 우열을 판단하기에 한계가 있다. 현재 공개된 에페의 임상 수치는 40주차 3상 중간 결과다. 한미약품 비만 신약 '에페' 로고 [사진=한미약품] ◆ 국내 환자 448명 임상으로 차별화, 브랜드·시장 경험은 숙제 이에 한미약품이 강조하는 에페의 차별점은 국내 환자를 대상으로 직접 확보한 임상 데이터다. 에페 임상 3상은 국내 성인 비만 환자 448명을 대상으로 실시했다. 위고비 역시 한국인을 포함한 아시아 환자 대상 임상을 진행했지만 에페는 3상 전체를 국내 비만 환자로 구성했다. 한미약품은 국내 환자로 구성된 임상을 통해 한국 진료현장에서 참고할 수 있는 데이터를 확보했다는 점을 차별화 요소로 내세운다. 다만 국내 환자 대상 임상이라는 사실 자체가 기존 치료제보다 높은 효능이나 안전성을 의미하는 것은 아니다. 임상에서 체질량지수(BMI) 30㎏/㎡ 미만 여성 환자의 평균 체중은 12.20% 감소했다. 한미약품은 이를 토대로 고도비만 환자뿐 아니라, 비만도가 낮거나 장기적인 체중 관리가 필요한 환자까지 처방 수요를 넓힐 수 있을 것으로 보고 있다. 한미약품은 에페가 GLP-1 비만치료제의 대표적인 부작용인 구역과 구토 등 위장관계 이상반응이 기존 제품 대비 낮다는 점도 내세우고 있다. 구역과 구토는 비만치료제의 투약을 중단하게 하는 요인으로 거론된다. 그러나 브랜드 인지도와 시장 경험에 있어서는 선발주자의 우위가 뚜렷하다. 위고비와 마운자로는 각각 노보 노디스크와 일라이 릴리라는 글로벌 대형 제약사의 제품으로, 해외에서 이미 대규모 판매와 처방 경험을 축적했다. 환자들의 실제 사용 경험과 장기 데이터가 쌓였다는 점도 후발주자인 에페가 단기간에 따라잡기 어려운 부분이다. 반면 한미약품은 국내 병·의원을 대상으로 구축한 영업망과 자체 생산능력을 갖추고 있다. 기존 영업망을 치료제 처방으로 연결할 수 있느냐가 후발주자의 한계를 극복할 변수가 될 것이라는 평가가 나온다. 한미약품은 에페를 연 매출 1000억원 이상 품목으로 육성한다는 목표를 세웠다. 목표 달성을 위해서는 가격 경쟁력 등 회사가 내세운 강점을 처방 확대로 연결할 수 있어야 한다.  한 업계 관계자는 "에페는 가격과 국내 환자 대상 임상 데이터에서 차별화 요소가 있지만 위고비와 마운자로는 높은 인지도와 처방 경험을 확보한 제품"이라며 "후발주자인 만큼 실제 진료 현장에서 의사와 환자의 선택을 얼마나 바꿀 수 있느냐가 시장 안착의 관건"이라고 봤다. sykim@newspim.com 2026-09-17 15:33
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李, 일정 최소화 '18일 회견' 준비 몰두 [서울=뉴스핌] 김미경 기자 = 이재명 대통령이 18일 기자회견을 하루 앞둔 17일 공식 일정을 최소화하고 회견 준비에 몰두했다. 이 대통령은 지난 14일부터 3일간 중앙아시아 5개국 정상과 연쇄 회담을 하고 1차 한-중앙아시아 정상회의를 주재하며 외교 일정으로 숨가쁘게 지냈다.  이 대통령이 기자회견 일정을 18일로 정한 것도 외교 일정을 모두 마무리하고 하루 정도 준비하는 시간이 필요하다는 판단을 한 것으로 보인다.  이 대통령은 이날 통상 목요일에 열던 수석보좌관회의도 없이 파티 비롤 국제에너지기구(IEA) 사무총장을 접견하는 일정만 소화한다.  이재명 대통령이 취임 1주녁 기자회견에서 주택공급을 위해 재건축·재개발도 속도를 내야한다고 말했다. [사진=청와대]  ◆청와대 "국민이 궁금한 국정 현안, 진솔하게 소통할 것" 이 대통령은 비롤 사무총장 접견 외 나머지 시간은 회견 준비에 쓸 것으로 예상된다. 이 대통령은 참모들에게서 분야별 핵심 쟁점과 추진 방향을 보고받고 예상 질문을 추려 답변을 거듭 다듬는 것으로 알려졌다. 회견은 18일 오전 10시 청와대 영빈관에서 열린다. 모두발언과 질의응답, 마무리 발언을 합쳐 90분가량 진행한다는 계획이다. 기자회견에는 내·외신 기자 150여 명이 참석한다. 질의응답은 정치·외교와 정책·경제 두 분야로 나눠 주제 제한 없이 진행하고 실시간 국민 댓글도 소개한다. 청와대는 회견 제목을 수식어 없이 '이재명 대통령 기자회견'으로 정했다. 회견장 배경막에는 '국민의 뜻, 국민의 삶, 더 살피겠습니다'라는 문구를 건다. 성기홍 청와대 홍보소통수석은 지난 15일 브리핑에서 "대통령의 확고한 개혁 의지와 민생 최우선 국정 기조, 더 단단한 국민 통합의 메시지를 전하는 자리가 될 것"이라고 했다. 이어 "국민이 궁금해하고 듣고 싶어 하는 국정 현안을 진솔하고 충실하게 소통하려 한다"고 설명했다. [서울=뉴스핌] 이건주 기자 = 8일 오전 서울 중구 하나은행 딜링룸에서 이재명 대통령 취임 1주년 기자회견 '대체불가 대한민국'이 생중계되고 있다. 2026.06.08 kunjoo@newspim.com ◆연임·공소취소·파병 정치 현안에 부동산·증시 민생 현안 산적  회견의 관심은 산적한 현안에 이 대통령이 과연 명확한 입장을 밝힐 것인지다. 특히 공소 취소와 연임 헌법 개정(개헌) 논란은 피할 수 없는 질문이다. 집권 여당인 더불어민주당은 '조작기소 특검법안'을 9월 중 처리하겠다고 예고했다. 특검에 공소취소 권한을 줄지가 핵심 쟁점이다. 이 대통령 사건 공소 취소를 앞장서 주장했던 김승원 의원이 법무부 장관 후보자로 지명됐고 민주당 주도로 국회 인사청문 경과보고서가 채택됨에 따라 야권의 공세는 더 거세졌다. 인사 검증 문제에 대한 언론의 질의도 예상된다. 용혜인 전 성평등가족부 장관 후보자는 자진사퇴했고 김승원 후보자는 '식약처 청탁 의혹'에 휩싸였다. 미국 요청에 따른 호르무즈 해협 파병 검토와 대미 투자 협상 관련 질문도 이 대통령에게는 고난도 문제다.  민생 현안으로는 부동산이 첫손에 꼽힌다. 정부는 취임 후 8·13 대책을 포함해 6차례 부동산 대책을 내놨다. 하지만 한국부동산원 집계에 따르면 서울 아파트 주간 매매 가격이 지난해 2월 첫째 주부터 83주 연속 올랐다. 문재인 정부 시절 세운 최장 기록(85주)에 바짝 다가섰다. 강남 3구 집값은 약세로 돌아섰지만 수도권 중저가 아파트값이 오르고 전세 매물 품귀와 월세 상승이 이어지고 있다. 부동산 정책 효과에 대한 논란이 적지 않다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆이 대통령 "임기는 헌법상 명확하게 제한"…이번엔 어떤 답 낼까 이 대통령이 앞서 일부 현안에 짧게 입장을 밝히기는 했지만 대체로 원론적 언급에 그친 경우가 많았다.  연임 개헌 논란을 두고는 프랑스 국빈방문 중이던 지난 9일(현지시간) 파리 동포 오찬간담회에서 "(대통령) 임기는 헌법상 명확하게 제한돼 있다"고 했다. 취임 초 해외 순방을 자주 다니는 이유를 설명하는 차원의 언급이었지만 연임 논란을 의식한 우회적 입장 표명이라는 해석이다.  공소 취소와 관련해서는 지난 6월 8일 진행한 취임 1주년 회견에서 "(조작기소 여부의) 진상 규명은 해야 한다"는 원론적 답변을 내놨다. 이 대통령은 당시 공소 취소 특검에 대한 질문을 받고 "결론적으로 법과 상식대로 하면 된다"며 "최소한의 진상규명을 해야 한다"고 했다. 이 대통령은 "뭔가 문제는 있어 보인다. 주관적 판단은 있지만 객관적으로도 문제가 있어 보이는 것이 꽤 많다"며 "잘못된 게 있으면 바로 잡고 없으면 그냥 놔두면 된다. 잘못됐으면 취소하고 잘못된 게 아니면 놔두는 것"이라고 했다. 사실상 공소가 잘못됐으면 바로 잡아야 한다는 취지의 설명이었다.  ◆여권에서도 "공소취소·연임 명확한 입장 내야" 목소리 강해   야권뿐 아니라 여권에서도 이 대통령이 민감한 현안에 대해 명확한 입장 표명을 해야 한다는 목소리가 강하다. 장동혁 국민의힘 대표는 이날 최고위원회의에서 "기자회견이 의미가 있으려면 그동안의 오만과 무능부터 국민에게 사과해야 한다"며 "부동산과 이란 파병 문제 등 모든 정책에서 국정 기조 대전환을 선언하고 국민이 납득할 분명한 답을 내놓길 바란다"고 요구했다. 한병도 민주당 원내대표는 정책조정회의에서 "기자회견은 국민 목소리를 경청하고 국정 현안을 두고 진솔한 대화를 나누는 소통의 장이 될 것"이라고 강조했다.  이광재 민주당 의원은 "공소 취소는 정무적이고 정치적인 문제이니 대통령이 언급할 것으로 본다"고 했다. 여권의 한 중진 의원은 "대통령이 연임 개헌이나 공소 취소와 관련해 명확한 입장을 내놓지 않는다면 향후 국정 운영이 쉽지 않을 것"이라고 우려했다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆9주 연속 지지율 하락…추석 전 기자회견, 반등 할까  이번 기자회견은 추석 연휴를 앞두고 열리는 만큼 지지율 반등의 분수령으로 꼽힌다. 여론조사 전문기관 리얼미터가 14일 공개한 9월 2주차 주간동향(에너지경제신문 의뢰, 7~11일, 무선 자동응답 방식 조사, 표본오차는 95% 신뢰수준에 ±2.0%포인트, 중앙선거여론조사심의위원회 홈페이지 참조)을 살펴보면 이 대통령의 국정수행 긍정평가는 9주 연속 하락해 취임 후 최저치인 33.8%였다. 부정평가는 63.3%로 처음 60%대에 올라섰다. 리얼미터는 외교 행보에도 개각 인선 논란과 호르무즈 파병 검토, 부동산 정책 불확실성이 겹친 데다 진보층과 20대 이탈이 더해진 것을 하락 주요 원인으로 분석했다.  한국갤럽이 17일 발표한 '2026 대한민국 신뢰도 조사'(시사IN 의뢰, 6~8일, 유선전화와 휴대전화 무작위 전화걸기 전화면접조사)에서는 이 대통령이 정치인 중 2위로 내려앉았다. 이 대통령은 2021년 이후 해당 조사에서 줄곧 가장 신뢰하는 정치인 1위였다. 올해 조사에서는 한동훈 무소속 의원에게 1위를 내줬다.  이 대통령에 대한 신뢰도 조사에서는 '신뢰한다' 35.9%, '불신한다' 50.4%였다. 지난해 조사에서는 이 대통령을 신뢰한다는 응답이 51.2%, 불신한다는 응답이 34.1%였다. 신뢰와 불신의 국민 평가가 1년 만에 뒤집어졌다.  the13ook@newspim.com 2026-09-17 14:37
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