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※ 번역할 언어 선택

State of the U.S. Economy

William Poole*
President, Federal Reserve Bank of St. Louis

AAIM Management Association
St. Louis
Feb. 9, 2007

*I appreciate comments provided by my colleagues at the Federal Reserve Bank of St. Louis. Kevin L. Kliesen, associate economist in the Research division, provided special assistance. However, I take full responsibility for errors. The views expressed are mine and do not necessarily reflect official positions of the Federal Reserve System.
State of the U.S. Economy

I am pleased to be here today to discuss the state of the U.S. economy and the near-term outlook. Despite some variability in quarterly growth rates last year, primarily related to declines in housing investment, the state of our economy looks good. The U.S. economy is highly productive, profit-making opportunities abound, interest rates and inflation are both relatively low and stable. The largest challenge facing the United States is not the business cycle but the task of adjusting on many fronts to the retirement of the baby boom generation. Fortunately, U.S. laws and institutions will enable us to face these challenges with a greater deal of optimism than in some other countries that will face the demographic challenge sooner and in larger measure than we will.

As background for discussing the economic outlook I’ll start by presenting a birds-eye view of recent developments in the U.S. economy, including those on the inflation front. Although my main topic is prospects for the U.S. economy over the next year or so, I do want to say a few words about some of the economic implications of long-run demographic change.

Before proceeding, I want to emphasize that the views I express here are mine and do not necessarily reflect official positions of the Federal Reserve System. I thank my colleagues at the Federal Reserve Bank of St. Louis for their comments, especially Kevin L. Kliesen, associate economist in the Research division, who provided special assistance. However, I retain full responsibility for errors.
The Big Picture

The U.S. economy is fundamentally sound. Over the past few years, surveys of business economists by the National Association for Business Economics have regularly pointed to key sources of strength. These include a dynamic and flexible labor market and a financial system that rewards innovation and risk-taking by channeling capital to its highest rates of return. In short, our market-based economy affords firms the ability and the incentive to innovate and to adapt quickly to changes in relative demands for goods and services. Managements today respond promptly to various shocks that rattle the economy. The growing dynamism of the U.S. economy is nicely illustrated by the rise in the economy’s rate of productivity growth that began around 1995—a change of enormous importance. It does not yet appear that the current productivity boom has run its course.

The rise in productivity growth has increased the economy’s potential output growth. At present, many economists estimate the potential growth rate at between 3 and 3.5 percent. From mid-2003 to the beginning of 2006, the U.S. economy’s actual real GDP growth was above the growth of potential. Over this period, the economy’s growth could exceed long-run potential because the economy was recovering from the 2001 recession. Given that the economy’s actual growth cannot permanently exceed its potential growth, it was inevitable that some slowing was to occur. And, indeed, during the second and third quarters of 2006, real GDP growth averaged about 2¼ percent, considerably less than the roughly 3¾ percent growth experienced from the second quarter of 2003 to the first quarter of 2006. As the growing economy absorbed underutilized labor and capital resources, the Fed gradually raised its target for the federal funds rate from 1 percent in 2004 to 5¼ percent in June of last year. The fed funds target rate remains today at 5¼ percent.

Monetary policy actions kept inflation largely, though not perfectly, in check and likely had something to do with the timing of slower GDP growth. I emphasize timing because slower GDP growth was inevitable as the margin of underutilized resources fell. As is so often the case, certain characteristics of the economic slowdown had little or nothing to do with monetary policy. Two other developments were important determinants of the nature of the economy last year. One was the sharp run-up in energy prices, which began to be reversed in the middle of 2006. The other was substantial weakness in housing markets, which may just now be showing very tentative signs of reaching bottom.

Three remarkable facts deserve attention. First, real GDP growth, though sluggish in 2002, has been robust since 2003, and the unemployment rate is now down to 4.6 percent. Second, long-term inflation expectations have hardly budged. Third, the quarterly average yield on 10-year nominal Treasury securities is actually slightly lower today than it was in mid 2002. The economy has performed well despite a near tripling of crude oil prices since December 2001. In years past, an energy price shock of this magnitude was typically associated with a substantial increase in inflation and a sharp recession.

Two things are different about energy price increases this time. One is that the increases were primarily a consequence of a booming world economy, which raised energy demand rather than a supply shock. Second, monetary policies here and in most other countries have done a fine job of anchoring inflation expectations.

The current housing slowdown, which is much in the news, is unusual in that it has not occurred against the backdrop of an economy-wide recession, when especially large declines in real residential fixed investment typically occur. For example, real residential fixed investment declined by about 40 and 45 percent, respectively, in the periods surrounding the 1973-75 and 1980-82 recessions.(1) By contrast, real residential fixed investment has declined by about 13 percent since its peak in the third quarter of 2005.

Let me now turn to current economic developments in more detail, which will set the stage for the outlook portion of my talk. As I step back and survey the economic landscape, I see an economy that appears to be transitioning quite nicely from last year’s slow patch to more sustainable growth.
Current Developments

During the past week or so we have seen a dizzying array—though typical, I might add—of economic reports. As usual, some were good and some were so-so. As usual, we need to be aware that first releases of data are often revised.

On balance, there seems to be a firmer tone to the latest data. Particularly noteworthy was the larger-than-expected increase in real GDP during the fourth quarter of 2006. Following relatively anemic rates of growth in the second and third quarters of 2006, growth of real GDP during the fourth quarter picked up nicely, rising to a 3.5 percent annual rate. Keep in mind, though, that this estimate is the first for the fourth quarter and subject to revision. Measuring GDP growth over the four quarters of the year, real GDP increased by more than 3 percent for the fourth straight year. A closer look at the GDP report reveals that two areas of strength were real consumer outlays and foreign purchases of U.S. goods and services. To some extent, the former reflects the decline in energy prices that began in the middle of last year, which has restored some of the purchasing power that was lost when gasoline prices rose well above $3 per gallon in many parts of the country. The latter probably reflects the improving growth prospects for the rest of the world. Another striking aspect of the report was the 4.2 percent growth in real final sales. Hence, despite a modest downturn in inventory investment, which nevertheless remained positive, real GDP growth was quite strong.

Two other aspects of the GDP report were less favorable than the overall report. First, business fixed investment posted a slight decline in the fourth quarter. I suspect that the decline was nothing more than normal variation, perhaps a consequence in part of firms waiting for release of the new Vista operating system from Microsoft. Over the four quarters of 2006, nonresidential fixed investment rose by 6.8 percent, a healthy and expected increase given that the economy has continued to absorb excess capacity. At this point, forecasts still point to a healthy pace of growth in business capital outlays this year—and perhaps the better-than-expected increase in December factory orders is a reflection of this expected growth. Nonetheless, extension of the fourth quarter weakness in business capital outlays going forward certainly would be a cause for concern.

The second aspect of the GDP report that garnered a lot of attention was the nearly 20 percent rate of decline in residential fixed investment. The decline began in the second quarter and the pace of decline picked up in each subsequent quarter. Naturally, the sharp decline in private housing starts and sales imparted a significant drag on real GDP growth last year. During the second half of 2006, the contribution to real GDP growth from real residential fixed investment averaged about –1¼ percentage points.

Last year was a difficult environment for homebuilders. It was also difficult for some homeowners in those parts of the country where the pace of home price appreciation slowed to a standstill. I’ll focus on new single-family homes, since that is the dominant part of the new-home market; the number of multi-family units started has remained relatively constant since 1997, at about 340,000 units per year.

Following a record-setting rate of 1.7 million units started in 2005, single-family starts fell to 1.5 million units in 2006. This average, though, reflected a relatively large number of starts during the first half of the year and then a much lower level of starts during the second half of 2006. By December 2006, single-family starts were roughly 16.5 percent below their annual average.

In 2006, new home sales fell about 17¼ percent to a little more than 1 million units and builders soon found themselves facing an accumulation of unsold homes. As a result, inventories of new homes rose sharply relative to sales, and in July 2006 the inventory-sales ratio reached its highest level in more than 10-years.

In response, builders naturally began to reduce new construction. Part of this pullback was motivated by skittish households; cancellation rates, according to some large builders, reached 40 percent or more during the latter part of 2006. Although the majority of forecasters correctly anticipated softness in housing construction, the magnitude of the decline exceeded their expectations. In December 2005, the consensus of the Blue Chip forecasters was that real residential fixed investment would decline by only about 1.4 percent in 2006, using annual average data. Instead, the decline was about 4¼ percent, but was considerably steeper—more than 12.5 percent—measured from the fourth quarter of 2005 to the fourth quarter of 2006.

By some indicators, the housing market is beginning to show signs of stabilizing. New single-family home sales rose in December, the fourth increase in the past five months, while in January the National Association of Home Builders’ housing market index—a measure of builder confidence—rose to its highest level since July 2006. Further, the four-week moving average of the Mortgage Bankers Association index of applications for home purchases has increased nicely since its trough last October. Finally, the University of Michigan’s consumer survey of home-buying conditions in January 2007 reportedly rose to its highest level since mid-2005.

The market for previously sold single-family homes may also have stabilized. Existing home sales rose a modest 0.1 percent in the fourth quarter of 2006, after declining 6.4 percent in the third quarter. Moreover, the pending home sales index reported by the National Association of Realtors turned up in January, registering its largest monthly increase since March 2004. Although the inventory of existing homes for sale, relative to sales, has also dropped over the past few months, its December level of 6.5 was still a bit above that for new homes, which stood at 5.9.

While recent data seem to point in a favorable direction, we must recognize that the housing market is not out of the woods yet. The most pressing issue for builders remains the backlog of unsold homes, at which they are chipping away, and the continued high rates of canceled orders.

A special word of caution is in order concerning housing data. Starts and permits data are routinely affected by weather variations, especially in the winter. To an unusual degree, sales data are affected by cancellations, which occur when buyers walk away from sales contracts. In published data, cancelled sales are not subtracted from new sales to create a net sales series. Moreover, cancelled sales are not put back into the data on the inventory of unsold new homes. Anecdotal reports clearly indicate that cancellations have been material. Thus, official data overstate net sales of new homes and understate the inventory of unsold homes. Finally, favorable recent news on the inventory of existing homes for sale may well have been influenced by discouraged homeowners taking their properties off the market rather than by actual sales.

House price data are also subject to distortions. For existing homes, the median sales price data released by the National Association of Realtors (NAR) show a decline starting in August and continuing every month except for a solid recovery in December. However, median price data can be distorted by a changing mix of sales. Fewer sales of high-end homes will reduce the median. Data released by the Office of Housing Enterprise Oversight (OFHEO) are not subject to this problem, but only cover homes financed by conforming mortgages, which are currently capped at $417,000. Although a changing mix of homes sold is not a problem with this series, high-end homes are excluded altogether. The OFHEO home price series derived from mortgage data for newly purchased homes shows an annual rate of price change of only about 1.5 percent in the third quarter of 2006, the latest data available as of this time.

To avoid the statistical limitations of the NAR and OFHEO price data, we can turn to the Case-Shiller price series for 20 cities, available through November 2006. The 20-city composite series shows declines for both October and November; in November, the series was only 1.7 percent above its prior year level. Moreover, the November decline from October occurred in 17 of the 20 cities.

My summary conclusion on home prices is that we have evidence of pervasive weakness last year. It remains to be seen what this year will bring, but at a minimum we can say that we do not have evidence as yet that home prices have stabilized.

For forecasters and policymakers, a key unknown is the long-run sustainable level of housing starts going forward. If the recent rate of starts has been above this sustainable rate, then we would expect to see an extended period of slower-than-normal activity until the inventory bulge is worked off. By the same token, if starts have fallen to a level that is below their sustainable rate, then we can expect that the inventory bulge will be worked off this year, so that the level starts will to return to their normal rate sometime later this year.

Statistically, there are several ways to estimate the normal level of starts. A common method is to estimate a model of some sort. For our purposes, assume that single-family housing starts in any year is a function of three primary variables: interest rates, household income and demographics.(2) In 2006, a model of this sort projected that housing starts would total about 1.7 million units, about 12.5 percent more than the actual level of about 1.5 million units. Assume: 1) no change in the average level of interest rates this year (relative to 2006); 2) that real GDP increases by 3 percent this year; and 3) that the number of households increases by 1 percent. With these assumptions, the model predicts that single-family housing starts will total about 1.4 million units this year, which we can compare to the actual 1.5 million units in 2006. This projection for 2007, which would be a 2.5 percent decline from 2006’s average, appears to be at the high-end of most forecasters’ expectation, perhaps because the model just outlined makes no allowance for the overhang of excessive inventory at the beginning of this year. But, eventually, as the inventory is worked off, home-building activity should pick up substantially from the 2006 year-end level of about 1.2 million units at an annual rate.

Some economists have worried that a potential side effect from the housing recession would be to drag down consumer spending more generally as home prices leveled off. Yet, as the fourth-quarter GDP report revealed, real consumer outlays appear to be holding up well.

The strength of consumer outlays is surely due to a sustained healthy labor market outlook, which we can expect to help keep consumer spending on a solid footing this year. Although last week’s employment report showed that job gains in January were a bit below expectations, job gains over the previous months were revised substantially higher as a result of the annual benchmark revision to the establishment survey by the Bureau of Labor Statistics. According to the BLS, nonagricultural payroll employment in the benchmark month—March 2006—was revised up by 752,000, an unusually large revision. Average monthly job gains from March 2006 to December 2006 were also boosted, from their original estimate of 148,000 per month to 174,000 per month.

Data revisions are one of the numerous sources of uncertainties that face monetary policymakers. The reason is that our current policies are always calibrated to the data that present themselves to us today—in real-time—and how the data map into the near-term outlook for economic activity and inflation. There is always the risk that our current policy can inadvertently be either be too restrictive or too stimulative. That’s part of the challenge of making monetary policy. As I think you can see from my earlier remarks, we dig deeply into the data and our inferences from what we observe are not always in accord with a surface reading of the data.
Recent Inflation Developments

I’ll now discuss recent developments on the inflation front. Last year’s CPI inflation news was somewhat peculiar in that, over the 12 months ending December 2006, inflation measured by the all-items CPI—sometimes called “headline inflation”—declined but core inflation, which excludes food and energy prices, rose slightly. Headline CPI inflation slowed from 3.4 percent in 2005 to 2.6 percent in 2006, while the inflation rate measured by the PCE price index rose slowed from 2.9 percent to 2.3 percent over the same period.

The moderation of headline inflation is undoubtedly a reflection of the sharp decline in energy prices over the second half of 2006. Most economists believe that core inflation is a better measure of inflation pressures. The core PCE price index rose slightly from 2.1 percent in 2005 to 2.2 percent in 2006, and the core CPI index rose even more, from 2.2 to 2.6 percent.(3) Fortunately, core price pressures have eased of late: The three-month rate of change in the core PCE was 1.7 percent, while the six-month rate of change was 1.9 percent. Clearly, the momentum seems to be headed in a favorable direction, as last week’s FOMC press release noted.

But before we declare victory and head home, it’s wise to consider some of the upside risks that I worry about. One of these risks, as I’ve noted earlier, is the possibility that we might be underestimating the likely pace of economic activity. If we get an upside surprise on GDP growth, then monetary policy may have to be tightened somewhat.

Another risk is that labor productivity growth might be lower than currently expected. Data released just two days ago indicate that in 2006 the annual average increase in productivity in the nonfarm business sector was 2.1 percent, down slightly from the increase of 2.3 percent in 2005 and down substantially from the average rate of 3.2 percent for 2000-2004. Given that the economy’s potential growth depends on trend growth in productivity and in the labor force, we will have to watch trends in both of these closely in the years ahead.
Thinking about the Outlook

In its policy statement issued after the meeting last week, the FOMC noted that the economy seems likely to expand at a moderate pace over coming quarters. My own take on what “moderate pace” means is that real GDP is likely to increase by roughly 3 percent over the four quarters of this year—particularly if the housing market is near an inflection point and no longer a significant drag on growth. But I want to emphasize that fluctuations in growth are normal and that no policy action is necessarily indicated if growth comes in somewhat above or below that outlook. When data come in outside the range expected, we need to understand the reasons and the likelihood that the departure will be sustained unless there is an offsetting policy response. Only then does it make sense to consider a policy response.

Regarding the outlook for inflation, I’ve said for quite some time that it might take a while for underlying price pressures to recede. Recent inflation data themselves, and other information relevant to judging the inflation outlook, suggest that the inflation rate is likely to fall into a reasonable range this year. If, however, core inflation seems to be settling at a rate above 2 percent, then such an outcome would be unacceptable to me. I put a very high weight on the Fed’s responsibility to maintain low and stable inflation.

At some point we’ll almost certainly see some surprises in the data. Long experience with economic forecasts indicates that we need to consider as a standard feature of the environment GDP forecast errors in the neighborhood of 1½ percentage points on a four-quarter ahead horizon. Thus, a forecast of 3 percent GDP growth should be expressed as 3 percent plus or minus 1½ percent. From experience, an outcome in this range has a probability of about two-thirds. The other one-third probability is divided equally above and below the range. Thus, the probability of an outcome significantly different from the baseline forecast is not small. The FOMC is prepared to respond when the outcome promises to depart from the baseline in a sustained way.

Although incoming data will at some point surprise us, what should not be surprising is the Fed’s commitment to maintaining price stability. Inflation forecasts over the next four quarters are also subject to standard errors. Over a longer horizon, though, the inflation issue is not one of forecast errors but of policy commitment and policy errors. My commitment, certainly, is to do what I can to promote policy adjustments that will yield an inflation outcome, on average over a period of several years, centered on 1½ percent on the core PCE price index. Such an outcome will ensure that the FOMC maintains its current high level of credibility. Maintaining price stability is central to maximizing sustainable economic growth and the highest possible level of employment. Stable inflation also contributes greatly to the economy’s ability to adjust successfully to inevitable shocks. That has been the Fed’s message—and its stated policy—for many years. It has been a successful strategy.
Long-Run Challenges

In an outlook speech, I cannot skip the opportunity to discuss briefly the economic implications of the changing demographic situation in the United States and the rest of the world. Demands on government from our aging population center on, but are not confined to, financing this country’s two primary programs for the elderly—Social Security and Medicare. Chairman Bernanke recently testified before the U.S. Congress on this matter.(4)

The macroeconomic implications of demographic change are significant. The retirement of the baby boomers is expected to reduce the economy’s labor force participation rate dramatically. The participation rate is the percentage of persons age 16 and over in the labor force, either working or seeking work. Declining growth in the labor force has important implications for our long-run, sustainable growth of GDP.

In its latest Budget and Economic Outlook, the Congressional Budget Office estimates that the average annual growth of potential output from 1950 to 2006 was 3.4 percent. The 3.4 percent is divided between labor productivity growth of 1.8 percentage points and labor force growth of 1.6 percentage points. Over the next 10 years, the CBO expects these contributions to change dramatically. From 2007 to 2017, the CBO projects that productivity will increase by an average of 2 percent per year; however, owing to the gradual declines in the labor force participation rate, the growth of the labor force is projected to increase by an average of only 0.7 percent per year. Hence, the CBO projects the growth of the economy’s potential output will slow by about 0.75 percentage points in the coming decade to a little more than 2.5 percent. This projection, if accurate, has serious long-term implications.

In a previous speech, I discussed the possibility that participation rates among older workers might rise modestly in the coming years. If that happens, labor force growth will not slow as rapidly as some projections indicate because more people over age 65 will be continuing to work than past retirement patterns would lead us to expect.(5) But the demographics tell us that such an outcome only delays inevitable adjustment. It could be that more of those in the 65-69 age group might work than has been the case recently, but when those same persons become the 75-79 age group we can be pretty sure that most will be retired. Because labor represents the largest single input in U.S. production, GDP will eventually begin to exhibit a slower rate of growth unless there is an offsetting increase in the economy’s structural rate of productivity growth.(6) Because income for the country as a whole depends on production, slower growth in GDP and income implies slower growth in consumption of U.S. households.

The likely result is that, all else equal, a decrease in labor supply growth will lead to slower growth in our economic well-being. Since monetary policy can affect only prices and not quantities in the long run, the Fed cannot alter this situation.

My discussion of the macroeconomic outlook may seem somewhat abstract, as is unavoidably the case when discussing a GDP of $11.422 trillion. That is a larger number than I can comprehend. Slower growth in this number is also hard to make real to us as individuals. The demographic challenge, however, will be felt by every firm in the economy. I know that we at the Federal Reserve Bank of St. Louis are acutely aware of the significant number of employees retiring over the next decade. Those retiring employees are our little piece of the nation’s demographic challenge. My confidence in the United States meeting the challenge reflects my confidence in the nation’s decentralized market system. Individual firms will adjust, by persuading some employees to retire later, by moving younger employees more quickly into positions of responsibility and by substituting capital for labor. The challenge for governments will be more difficult, because political decisions are not reached as easily as decisions in individual firms. Still, if we approach the political issues with full understanding of the fundamentals of the demographics and with the spirit of compromise that characterizes our democracy, I am confident that we’ll come out the other side of the demographic transition in fine shape.
References

Bernanke, Ben S. “Long-term Fiscal Challenges Facing the United States,” Testimony Before the Committee on the Budget, U.S. Senate, Jan. 18, 2007.

Congressional Budget Office. “The Budget and Economic Outlook: Fiscal Years 2008 to 2017,” January 2007.

Poole, William. “U.S. Labor Input in Coming Years,” Remarks to the Chartered Financial Analysts Society of Philadelphia, Wilmington, Del., Nov. 14, 2006.
Footnotes

1. These two periods are 1973:Q1 to 1975:Q1 and 1978:Q3 to 1982:Q3. The latter period encompasses the 1980 and 1981-82 recessions.
2. The model specifies the log-level of single-family starts as a function of the level of the 10-year Treasury yield, the log-level of households and the log-level of real GDP. The model is an ARMA specification of AR (1) and MA (2). The model uses annual data, 1965 to 2006. Further details are available on request.
3. Inflation is measured as the percent change, December to December.
4. See Bernanke (2007).
5. See Poole (2006).
6. Of course, this assumes that immigration rates or changes in fertility rates do not materially alter the projected growth of potential labor force.

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위고비에 도전한 새 비만약 '에페' 가격은? [서울=뉴스핌] 김신영 기자 = 한미약품의 국산 비만 신약 '에페'가 위고비와 마운자로가 86%를 장악한 국내 비만치료제 시장에 뛰어든다. 후발주자인 만큼 자체 생산을 통한 가격 경쟁력과 국내 환자 임상 데이터, 기존 병·의원 영업망을 앞세워 선발 제품 중심의 처방 시장을 파고든다는 전략이다. 관건은 가격 이외의 경쟁력을 실제 처방 전환으로 연결할 수 있느냐다. 위고비와 마운자로는 글로벌 시장에서 이미 높은 인지도와 장기간의 처방 경험을 쌓은 데다 대표 임상에서 높은 체중 감량 효과를 제시했다. 에페가 연매출 1000억원 목표를 달성하려면 가격에 민감한 신규 수요를 확보하는 동시에 기존 GLP-1 치료제 사용자의 선택까지 끌어와야 한다. 17일 제약·바이오업계에 따르면 한미약품은 오는 10월 식품의약품안전처 품목허가를 목표로 에페(성분명 에페글레나타이드) 출시를 준비하고 있다. 허가 이후 연내 출시가 목표다. 한미약품 본사 전경 [사진=한미약품] ◆ 가격 경쟁력 갖췄지만…출시 이후 기존 제품 인하 변수 에페는 한미약품이 자체 개발한 주 1회 투여 글루카곤 유사 펩타이드(GLP-1) 계열 비만치료제다. 약물이 체내에서 오래 작용하도록 한 한미약품의 지속형 플랫폼 기술 '랩스커버리'가 적용됐다. 에페가 진입할 시장은 이미 선발주자 중심으로 2강 구도가 형성돼 있다. 의약품 시장조사기관 아이큐비아에 따르면 국내 비만치료제 시장은 2024년 2426억원에서 지난해 8195억원으로 1년 만에 3배 이상 확대됐다. 이 중 위고비와 마운자로 판매액은 각각 4833억원, 2209억원으로 두 제품이 전체 시장의 약 86%를 차지했다. 후발주자인 에페가 내세운 무기는 가격이다. 한미약품은 최종 공급가를 공개하지 않았지만 업계와 증권가에서는 4주 투약 기준 10만원대 가격이 거론된다. 현재 위고비의 시작용량인 0.25㎎의 4주분 공급가는 21만6000원, 마운자로의 시작용량인 2.5㎎은 27만8000원 수준이다. 한미약품이 가격 경쟁력을 확보할 수 있는 배경에는 자체 생산체제가 있다. 회사는 경기도 평택 바이오플랜트에서 에페를 직접 생산한다. 외부 생산 의존도를 낮춰 공급 안정성을 높이는 동시에 가격을 낮추겠다는 구상이다. 하지만 가격만으로 선발주자의 벽을 넘을 수 있을지는 미지수다. 국내에서 가장 먼저 출시된 비만치료제인 위고비는 마운자로의 국내 출시를 앞둔 지난해 용량별 차등가격제를 도입하면서 시작용량 공급가를 기존 37만2000원에서 21만6000원으로 약 42% 낮췄다. 경쟁 제품 등장에 맞춰 선발주자가 가격을 조정한 전례가 있는 만큼 에페 출시 이후 추가 가격 경쟁이 벌어질 가능성도 제기된다. 비만치료제의 핵심 경쟁력은 체중 감량 효과다. 한미약품이 공개한 에페 임상 3상 40주차 중간 결과에서 평균 체중 감소율은 9.75%였다. 체중이 5% 이상 감소한 환자는 79.42%, 10% 이상은 49.46%, 15% 이상은 19.86%였다. 선발 제품들은 글로벌 임상에서 더 높은 체중 감소율을 제시했다. 위고비는 비만 또는 과체중 성인 1961명을 대상으로 한 STEP 1 임상에서 68주 투여 후 평균 체중이 14.9% 감소했다. 체중이 5% 이상 줄어든 환자는 86.4%, 10% 이상은 69.1%, 15% 이상은 50.5%였다. 마운자로는 비만 또는 과체중 성인 2539명을 대상으로 한 'SURMOUNT-1' 임상에서 72주 후 평균 체중 감소율이 5mg 투여군 15.0%, 10mg 19.5%, 15mg 20.9%로 나타났다. 15mg 투여군에서는 70.6%가 체중을 15% 이상 줄였고, 56.7%는 20% 이상 감량했다. 다만 에페와 위고비, 마운자로의 임상은 투약 기간과 대상 환자, 용량과 시험 설계 등이 달라 체중 감소율을 단순 비교해 우열을 판단하기에 한계가 있다. 현재 공개된 에페의 임상 수치는 40주차 3상 중간 결과다. 한미약품 비만 신약 '에페' 로고 [사진=한미약품] ◆ 국내 환자 448명 임상으로 차별화, 브랜드·시장 경험은 숙제 이에 한미약품이 강조하는 에페의 차별점은 국내 환자를 대상으로 직접 확보한 임상 데이터다. 에페 임상 3상은 국내 성인 비만 환자 448명을 대상으로 실시했다. 위고비 역시 한국인을 포함한 아시아 환자 대상 임상을 진행했지만 에페는 3상 전체를 국내 비만 환자로 구성했다. 한미약품은 국내 환자로 구성된 임상을 통해 한국 진료현장에서 참고할 수 있는 데이터를 확보했다는 점을 차별화 요소로 내세운다. 다만 국내 환자 대상 임상이라는 사실 자체가 기존 치료제보다 높은 효능이나 안전성을 의미하는 것은 아니다. 임상에서 체질량지수(BMI) 30㎏/㎡ 미만 여성 환자의 평균 체중은 12.20% 감소했다. 한미약품은 이를 토대로 고도비만 환자뿐 아니라, 비만도가 낮거나 장기적인 체중 관리가 필요한 환자까지 처방 수요를 넓힐 수 있을 것으로 보고 있다. 한미약품은 에페가 GLP-1 비만치료제의 대표적인 부작용인 구역과 구토 등 위장관계 이상반응이 기존 제품 대비 낮다는 점도 내세우고 있다. 구역과 구토는 비만치료제의 투약을 중단하게 하는 요인으로 거론된다. 그러나 브랜드 인지도와 시장 경험에 있어서는 선발주자의 우위가 뚜렷하다. 위고비와 마운자로는 각각 노보 노디스크와 일라이 릴리라는 글로벌 대형 제약사의 제품으로, 해외에서 이미 대규모 판매와 처방 경험을 축적했다. 환자들의 실제 사용 경험과 장기 데이터가 쌓였다는 점도 후발주자인 에페가 단기간에 따라잡기 어려운 부분이다. 반면 한미약품은 국내 병·의원을 대상으로 구축한 영업망과 자체 생산능력을 갖추고 있다. 기존 영업망을 치료제 처방으로 연결할 수 있느냐가 후발주자의 한계를 극복할 변수가 될 것이라는 평가가 나온다. 한미약품은 에페를 연 매출 1000억원 이상 품목으로 육성한다는 목표를 세웠다. 목표 달성을 위해서는 가격 경쟁력 등 회사가 내세운 강점을 처방 확대로 연결할 수 있어야 한다.  한 업계 관계자는 "에페는 가격과 국내 환자 대상 임상 데이터에서 차별화 요소가 있지만 위고비와 마운자로는 높은 인지도와 처방 경험을 확보한 제품"이라며 "후발주자인 만큼 실제 진료 현장에서 의사와 환자의 선택을 얼마나 바꿀 수 있느냐가 시장 안착의 관건"이라고 봤다. sykim@newspim.com 2026-09-17 15:33
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李, 일정 최소화 '18일 회견' 준비 몰두 [서울=뉴스핌] 김미경 기자 = 이재명 대통령이 18일 기자회견을 하루 앞둔 17일 공식 일정을 최소화하고 회견 준비에 몰두했다. 이 대통령은 지난 14일부터 3일간 중앙아시아 5개국 정상과 연쇄 회담을 하고 1차 한-중앙아시아 정상회의를 주재하며 외교 일정으로 숨가쁘게 지냈다.  이 대통령이 기자회견 일정을 18일로 정한 것도 외교 일정을 모두 마무리하고 하루 정도 준비하는 시간이 필요하다는 판단을 한 것으로 보인다.  이 대통령은 이날 통상 목요일에 열던 수석보좌관회의도 없이 파티 비롤 국제에너지기구(IEA) 사무총장을 접견하는 일정만 소화한다.  이재명 대통령이 취임 1주녁 기자회견에서 주택공급을 위해 재건축·재개발도 속도를 내야한다고 말했다. [사진=청와대]  ◆청와대 "국민이 궁금한 국정 현안, 진솔하게 소통할 것" 이 대통령은 비롤 사무총장 접견 외 나머지 시간은 회견 준비에 쓸 것으로 예상된다. 이 대통령은 참모들에게서 분야별 핵심 쟁점과 추진 방향을 보고받고 예상 질문을 추려 답변을 거듭 다듬는 것으로 알려졌다. 회견은 18일 오전 10시 청와대 영빈관에서 열린다. 모두발언과 질의응답, 마무리 발언을 합쳐 90분가량 진행한다는 계획이다. 기자회견에는 내·외신 기자 150여 명이 참석한다. 질의응답은 정치·외교와 정책·경제 두 분야로 나눠 주제 제한 없이 진행하고 실시간 국민 댓글도 소개한다. 청와대는 회견 제목을 수식어 없이 '이재명 대통령 기자회견'으로 정했다. 회견장 배경막에는 '국민의 뜻, 국민의 삶, 더 살피겠습니다'라는 문구를 건다. 성기홍 청와대 홍보소통수석은 지난 15일 브리핑에서 "대통령의 확고한 개혁 의지와 민생 최우선 국정 기조, 더 단단한 국민 통합의 메시지를 전하는 자리가 될 것"이라고 했다. 이어 "국민이 궁금해하고 듣고 싶어 하는 국정 현안을 진솔하고 충실하게 소통하려 한다"고 설명했다. [서울=뉴스핌] 이건주 기자 = 8일 오전 서울 중구 하나은행 딜링룸에서 이재명 대통령 취임 1주년 기자회견 '대체불가 대한민국'이 생중계되고 있다. 2026.06.08 kunjoo@newspim.com ◆연임·공소취소·파병 정치 현안에 부동산·증시 민생 현안 산적  회견의 관심은 산적한 현안에 이 대통령이 과연 명확한 입장을 밝힐 것인지다. 특히 공소 취소와 연임 헌법 개정(개헌) 논란은 피할 수 없는 질문이다. 집권 여당인 더불어민주당은 '조작기소 특검법안'을 9월 중 처리하겠다고 예고했다. 특검에 공소취소 권한을 줄지가 핵심 쟁점이다. 이 대통령 사건 공소 취소를 앞장서 주장했던 김승원 의원이 법무부 장관 후보자로 지명됐고 민주당 주도로 국회 인사청문 경과보고서가 채택됨에 따라 야권의 공세는 더 거세졌다. 인사 검증 문제에 대한 언론의 질의도 예상된다. 용혜인 전 성평등가족부 장관 후보자는 자진사퇴했고 김승원 후보자는 '식약처 청탁 의혹'에 휩싸였다. 미국 요청에 따른 호르무즈 해협 파병 검토와 대미 투자 협상 관련 질문도 이 대통령에게는 고난도 문제다.  민생 현안으로는 부동산이 첫손에 꼽힌다. 정부는 취임 후 8·13 대책을 포함해 6차례 부동산 대책을 내놨다. 하지만 한국부동산원 집계에 따르면 서울 아파트 주간 매매 가격이 지난해 2월 첫째 주부터 83주 연속 올랐다. 문재인 정부 시절 세운 최장 기록(85주)에 바짝 다가섰다. 강남 3구 집값은 약세로 돌아섰지만 수도권 중저가 아파트값이 오르고 전세 매물 품귀와 월세 상승이 이어지고 있다. 부동산 정책 효과에 대한 논란이 적지 않다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆이 대통령 "임기는 헌법상 명확하게 제한"…이번엔 어떤 답 낼까 이 대통령이 앞서 일부 현안에 짧게 입장을 밝히기는 했지만 대체로 원론적 언급에 그친 경우가 많았다.  연임 개헌 논란을 두고는 프랑스 국빈방문 중이던 지난 9일(현지시간) 파리 동포 오찬간담회에서 "(대통령) 임기는 헌법상 명확하게 제한돼 있다"고 했다. 취임 초 해외 순방을 자주 다니는 이유를 설명하는 차원의 언급이었지만 연임 논란을 의식한 우회적 입장 표명이라는 해석이다.  공소 취소와 관련해서는 지난 6월 8일 진행한 취임 1주년 회견에서 "(조작기소 여부의) 진상 규명은 해야 한다"는 원론적 답변을 내놨다. 이 대통령은 당시 공소 취소 특검에 대한 질문을 받고 "결론적으로 법과 상식대로 하면 된다"며 "최소한의 진상규명을 해야 한다"고 했다. 이 대통령은 "뭔가 문제는 있어 보인다. 주관적 판단은 있지만 객관적으로도 문제가 있어 보이는 것이 꽤 많다"며 "잘못된 게 있으면 바로 잡고 없으면 그냥 놔두면 된다. 잘못됐으면 취소하고 잘못된 게 아니면 놔두는 것"이라고 했다. 사실상 공소가 잘못됐으면 바로 잡아야 한다는 취지의 설명이었다.  ◆여권에서도 "공소취소·연임 명확한 입장 내야" 목소리 강해   야권뿐 아니라 여권에서도 이 대통령이 민감한 현안에 대해 명확한 입장 표명을 해야 한다는 목소리가 강하다. 장동혁 국민의힘 대표는 이날 최고위원회의에서 "기자회견이 의미가 있으려면 그동안의 오만과 무능부터 국민에게 사과해야 한다"며 "부동산과 이란 파병 문제 등 모든 정책에서 국정 기조 대전환을 선언하고 국민이 납득할 분명한 답을 내놓길 바란다"고 요구했다. 한병도 민주당 원내대표는 정책조정회의에서 "기자회견은 국민 목소리를 경청하고 국정 현안을 두고 진솔한 대화를 나누는 소통의 장이 될 것"이라고 강조했다.  이광재 민주당 의원은 "공소 취소는 정무적이고 정치적인 문제이니 대통령이 언급할 것으로 본다"고 했다. 여권의 한 중진 의원은 "대통령이 연임 개헌이나 공소 취소와 관련해 명확한 입장을 내놓지 않는다면 향후 국정 운영이 쉽지 않을 것"이라고 우려했다.  이재명 대통령이 8일 청와대 영빈관에서 취임 1주년 기자회견을 하고 있다. 2026.06.08 [사진=청와대] ◆9주 연속 지지율 하락…추석 전 기자회견, 반등 할까  이번 기자회견은 추석 연휴를 앞두고 열리는 만큼 지지율 반등의 분수령으로 꼽힌다. 여론조사 전문기관 리얼미터가 14일 공개한 9월 2주차 주간동향(에너지경제신문 의뢰, 7~11일, 무선 자동응답 방식 조사, 표본오차는 95% 신뢰수준에 ±2.0%포인트, 중앙선거여론조사심의위원회 홈페이지 참조)을 살펴보면 이 대통령의 국정수행 긍정평가는 9주 연속 하락해 취임 후 최저치인 33.8%였다. 부정평가는 63.3%로 처음 60%대에 올라섰다. 리얼미터는 외교 행보에도 개각 인선 논란과 호르무즈 파병 검토, 부동산 정책 불확실성이 겹친 데다 진보층과 20대 이탈이 더해진 것을 하락 주요 원인으로 분석했다.  한국갤럽이 17일 발표한 '2026 대한민국 신뢰도 조사'(시사IN 의뢰, 6~8일, 유선전화와 휴대전화 무작위 전화걸기 전화면접조사)에서는 이 대통령이 정치인 중 2위로 내려앉았다. 이 대통령은 2021년 이후 해당 조사에서 줄곧 가장 신뢰하는 정치인 1위였다. 올해 조사에서는 한동훈 무소속 의원에게 1위를 내줬다.  이 대통령에 대한 신뢰도 조사에서는 '신뢰한다' 35.9%, '불신한다' 50.4%였다. 지난해 조사에서는 이 대통령을 신뢰한다는 응답이 51.2%, 불신한다는 응답이 34.1%였다. 신뢰와 불신의 국민 평가가 1년 만에 뒤집어졌다.  the13ook@newspim.com 2026-09-17 14:37
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